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首页> 外文期刊>Behavioral neuroscience >Gonadal Hormone Fluctuations Do Not Affect the Expression or Extinction of Fear-Potentiated Startle in Female Rats
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Gonadal Hormone Fluctuations Do Not Affect the Expression or Extinction of Fear-Potentiated Startle in Female Rats

机译：Gonadal激素波动不会影响母老鼠中恐惧有效的惊吓的表达或灭绝

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Prior studies suggest that levels of ovarian hormones may affect learning and memory in rats, including studies of fear conditioning and extinction. We previously showed that female rats show reduced retention of extinction compared to males when measuring fear-potentiated startle, but not when measuring freezing behavior. One commonly reported observation in studies of freezing behavior is that rats with increased levels of estradiol during extinction learning show better retention of extinction than rats given extinction training when levels of estradiol are low. Here, we tested the hypothesis that fear extinction retention in a fear-potentiated startle paradigm in females is influenced by levels gonadal hormones, which we had not accounted for in our original report. We used the fear-potentiated startle paradigm to test if extinction learning was affected by estrous phase, ovariectomy, or acute systemic injections of estradiol in ovariectomized rats. We report that neither the expression nor extinction of fear-potentiated startle differed in rats given extinction training in proestrus compared to those in metestrus. Removal of the ovaries had no effect on fear acquisition or extinction learning as assessed by fear-potentiated startle. Finally, systemic injections of estradiol given to ovariectomized rats before extinction training had no effect on the expression of fear or the retention of extinction. Our findings suggest that the effect of female gonadal hormones on fear conditioning and extinction may depend on the measure of fear employed or by the parameters used to study fear learning.
机译：事先研究表明，卵巢激素的水平可能会影响大鼠的学习和记忆，包括恐惧调理和灭绝的研究。我们以前表明，当测量恐惧调情的惊吓时，雌性大鼠与雄性相比，缺失减少了灭绝的保留，但是在测量冻结行为时不存在。在冻结行为的研究中常见的观察是，消化学习期间雌二醇水平增加的大鼠表现出比在雌二醇水平低的灭绝训练的大鼠的灭绝保留的最小值。在这里，我们测试了恐惧在女性中恐惧促进的惊人范式的灭绝保留的假设受到潜力素荷尔蒙的水平的影响，这在我们的原始报告中我们没有占据过。如果灭绝学习受卵巢切除大鼠在卵巢大鼠中雌二醇的雌二醇的影响，我们使用恐惧调节的惊吓范式来测试。我们报告说，与Metestrus中的那些相比，大鼠既不表达恐惧调强的惊吓患者不同的大鼠不同。除了恐惧调情的惊吓时，对卵巢的去除没有影响恐惧收购或灭绝学习。最后，在消灭训练前对卵巢切除大鼠发出的雌二醇的全身注射对恐惧的表达或灭绝的抑制没有影响。我们的研究结果表明，女性性腺激素对恐惧调理和灭绝的影响可能取决于所用恐惧的措施或用于学习恐惧学习的参数。

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