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首页> 外文期刊>Behavioral neuroscience >Neuronal Activation in Orbitofrontal Cortex Subregions: Cfos Expression Following Cue-Induced Reinstatement of Cocaine-Seeking Behavior
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Neuronal Activation in Orbitofrontal Cortex Subregions: Cfos Expression Following Cue-Induced Reinstatement of Cocaine-Seeking Behavior

机译：在胰腺癌皮质次区域中的神经元激活：Cue诱导恢复可卡因寻求行为后的CFOS表达

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摘要

Cocaine-use disorders are characterized by repeated relapse to drug-seeking and drug-taking behavior following periods of abstinence. Former drug users display increased activation of the orbitofrontal cortex (OFC) in response to drug-related cues, and similar phenomena are also observed in rodent models of drug relapse. The lateral, but not medial, OFC functionally contributes to the maintenance of cue-drug associations; however, less is known about the role of the ventral OFC in this process. To examine the pattern of neuronal activation in OFC subregions in response to drug-associated cues, rats were trained to respond on a lever for a cocaine infusion paired with a complex cue (2-hr sessions, minimum 10 days). Cocaine self-administration was followed by extinction training, in which lever responses resulted in no consequences (2-hr sessions, minimum 7 days). During a 1-hr reinstatement test, drug-seeking behavior (i.e., responses on the drug-paired lever) was examined in the presence or absence of contingent drug-paired cues (Cue TEST vs. Ext TEST, respectively). Rats were overdosed with a ketamine + xylazine cocktail 30-min post session, and transcardially perfused with 4% paraformaldehyde. Cfos protein expression was utilized to measure potential changes in neural activation between the reinstatement test groups. An increase in the number of Cfos-Immunoreactive cells was observed in the ventral and lateral subregions of the OFC in the Cue TEST group. The present findings provide evidence that the ventral and lateral regions of the rat OFC display similar patterns of neuronal activation in response to cocaine-paired cues.
机译：可卡因使用障碍的特点是在禁欲期间重复复发到药物寻求和吸毒行为。以前的药物用户显示替代药物复发啮齿动物复发模型中也观察到类似的现象的增加的胰蛋白酶皮质皮质（OFC）的激活。 OFC的横向，但不是内侧，在功能上有助于维持提示药物关联;然而，关于腹侧腹侧的腹侧的作用，较少。为了响应于药物相关的提示，审查OFC次区域中神经元激活的模式，培训大鼠以响应与复杂提示（2-HR会话，最少10天）配对的可卡因输注的杠杆。随后可卡因自我管理是灭绝培训，其中杠杆响应没有后果（2小时课程，最少7天）。在1小时恢复试验期间，在存在或不存在或不存在或不存在或不存在或不存在的药物成对的提示（Cue试验与EXT测试的情况下，研究寻求药物行为（即，对药物配对杆的反应）。用氯胺酮+木嗪鸡尾酒30分钟后会议覆盖大鼠，并与4％多聚甲醛转过括起来。 CFOS蛋白表达用于测量恢复试验组之间神经活化的潜在变化。在CUE试验组的OFC的腹侧和侧次区域中观察到CFOS免疫反应细胞数量的增加。本研究结果提供了证据表明，响应于可卡因配对的提示，大鼠的腹侧和侧面呈现出类似的神经元激活模式。

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