首页> 外文期刊>Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences >Mobility of the Yersinia High-Pathogenicity Island (HPI): transfer mechanisms of pathogenicity islands (PAIS) revisited (a review).
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Mobility of the Yersinia High-Pathogenicity Island (HPI): transfer mechanisms of pathogenicity islands (PAIS) revisited (a review).

机译:耶尔森氏菌高致病性岛(HPI)的流动性:重新探讨了致病性岛(PAIS)的转移机制(综述)。

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摘要

Horizontal gene transfer (HGT) plays a key role in the evolution of bacterial pathogens. The exchange of genetic material supplies prokaryotes with several fitness traits enhancing their adaptive response to environmental changes. Pathogenicity islands (PAIs) represent an important and in most cases already immobilized subset of the different vehicles for HGT. Encoding several virulence factors PAls represent a major contribution to bacterial pathogenicity. Nonetheless, the transfer mechanisms of PAIs still remain elusive. We summarise the currently available data regarding the major ways of genetic mobilisation with a focus on the transfer of the Yersinia High-Pathogenicity Island (HPI).
机译:水平基因转移(HGT)在细菌病原体的进化中起关键作用。遗传物质的交换为原核生物提供了几种适应性特征,从而增强了它们对环境变化的适应性反应。致病性岛(PAI)代表了重要的且在大多数情况下已固定化的HGT不同工具的子集。编码几种毒力因子PA1代表细菌致病性的主要贡献。尽管如此,PAI的转移机制仍然难以捉摸。我们总结了有关基因动员的主要方式的当前可用数据,重点是耶尔森氏菌高致病性岛(HPI)的转移。

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