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首页> 外文期刊>Acta microbiologica et immunologica Hungarica: A quarterly of the Hungarian Academy of Sciences >Oral poliovirus vaccine in management of recurrent aphthous stomatitis.
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Oral poliovirus vaccine in management of recurrent aphthous stomatitis.

机译：口服脊髓灰质炎疫苗用于治疗复发性口疮性口炎。

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摘要

Oral poliovirus vaccine (OPV) is reported to be effective in treatment of recurrent herpes simplex (RHS). According to our observation during recent years, OPV was not only effective in management of RHS but also in some patients with concomitant recurrent aphthous stomatitis (RAS) reducing its severity and frequency. The purpose of this study was to evaluate the efficacy of OPV in the management of RAS. In a longitudinal, case--control study 48 patients with RAS were recruited. Twenty patients received OPV and 28 patients received placebo. OPV was administered in a dose of 4 drops at monthly intervals for 3 months to the study group while the control group received placebo. The results were registered in 3 months after the last dose. Eight cases (40%) in the OPV group showed significant reduction in the duration of the ulcers, while no change was seen in the control group (P = 0.048). The frequency of recurrence of RAS was reduced in 13 cases (65%) in the OPV group, and in 6 cases (21.4%) of the placebo group (P = 0.006). The severity of attacks was reduced in 12 cases (60%) in the OPV group and in 4 cases (14.3%) in the placebo group (P = 0.008). In conclusion OPV appeared to be effective in the management of RAS.
机译：口服脊髓灰质炎病毒疫苗（OPV）据报道可有效治疗复发性单纯疱疹（RHS）。根据我们最近几年的观察，OPV不仅对RHS的治疗有效，而且对某些伴发复发性口疮性口炎（RAS）的患者降低了其严重程度和频率。这项研究的目的是评估OPV在RAS管理中的功效。在一项纵向病例对照研究中，招募了48位RAS患者。 20例接受OPV，28例接受安慰剂。研究组每月一次以4滴的剂量口服OPV，持续3个月，而对照组则接受安慰剂。在最后一次给药后3个月内记录结果。 OPV组中有8例（40％）溃疡持续时间显着减少，而对照组则无变化（P = 0.048）。 OPV组13例（65％）的RAS复发频率降低，安慰剂组6例（21.4％）的RAS复发频率降低（P = 0.006）。 OPV组的发作严重程度降低了12例（60％），安慰剂组降低了4例（14.3％）（P = 0.008）。总之，OPV似乎对RAS的治疗有效。

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