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首页> 外文期刊>Critical Reviews in Food Science and Nutrition >Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies
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Does dietary intake of selenium protect against cancer? A systematic review and meta-analysis of population-based prospective studies

机译：膳食摄入硒防止癌症吗？ 基于人口的前瞻性研究的系统综述与荟萃分析

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摘要

Current evidence on selenium and its effects on cancer is conflicting. This study aimed at assessing the association between dietary intake of selenium and incidence of cancers by performing systematic review and meta-analysis of population-based prospective studies. We systematically searched for articles in Medline (Ovid), Embase, Web of Science (Thomson Reuters), China National Knowledge Infrastructure, Wanfang Database and VIP Chinese Scientific Journals. Analysis was performed in Stata version 14.2. Of the 2,564 articles obtained from the databases, 39 met our inclusion criteria, 37 were included in the final analysis. Selenium at recommended daily allowance levels of >= 55 mu g/day decreased the risk of cancer [relative risk (RR) = 0.94, 95% confidence interval (CI): 0.90-0.98]. A protective effect was found in men at levels >= 55 mu g/day (RR = 0.97, 95% CI: 0.94-0.99). Extra selenium intake from supplements was protective at levels >= 55 mu g/day (RR = 0.89, 95% CI: 0.82-0.97). There was an inverse relationship (p value = 0.020) between selenium intake and overall cancer risk after adjusting for age, body mass index, and smoking but there was no evidence of nonlinear relationship (p value = 0.261). The findings in this study suggest that selenium is protective against cancer however the effects vary with different cancers.
机译：关于硒的目前的证据及其对癌症的影响是矛盾的。本研究旨在通过对基于人口的前瞻性研究进行系统审查和荟萃分析来评估膳食摄入和癌症发病率之间的关联。我们系统地搜索了Medline（Ovid），Embase，Science Web（Thomson Reuters），中国国家知识基础设施，万方数据库和VIP中国科学期刊中的文章。分析在Stata版本14.2中进行。在数据库中获得的2,564篇文章中，39届符合我们的纳入标准，37次纳入最终分析。在建议的每日津贴水平> =55μg/天的硒减少了癌症的风险[相对风险（RR）= 0.94,95％置信区间（CI）：0.90-0.98]。在含量> =55μg/天（RR = 0.97,95％CI：0.94-0.99）的男性中发现保护效果。补充剂的额外硒摄入量适于水平> =55μg/天（RR = 0.89,95％CI：0.82-0.97）。在调整年龄，体重指数和吸烟后，硒摄入和整体癌症风险之间存在反相（P值= 0.020），但没有非线性关系的证据（P值= 0.261）。该研究的发现表明，硒对癌症进行了保护，但效果随不同的癌症而变化。

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