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首页> 外文期刊>Critical Reviews in Food Science and Nutrition >Dietary fats and F-2-isoprostanes: A review of the clinical evidence
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Dietary fats and F-2-isoprostanes: A review of the clinical evidence

机译：膳食脂肪和F-2 - 异己烷：对临床证据进行审查

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Evidence supports that a high dietary fat intake increases oxidative stress and the risk of diet-induced metabolic disorders such as obesity, diabetes and cardiovascular diseases. F-2-isoprostanes (F-2-isoP) are formed by the non-enzymatic oxidation of arachidonic acid and are widely used as reliable biomarkers of oxidative stress in clinical studies. Dietary fats may influence F-2-isoP levels, as they (1) are metabolic substrates for their formation, (2) modify the lipid composition of tissues, and (3) affect the plasma lipoprotein concentrations which are involved in F-2-isoP transport. This review examined the latest clinical evidence on how dietary fats can affect blood circulation and excretion of F2-isoP in individuals with healthy or deteriorated metabolic profiles. Clinical studies reported that saturated or monounsaturated fat-rich diets did not affect F-2-isoP levels in adults with healthy or deteriorated metabolic profiles. Though, omega-3 polyunsaturated fatty acids decreased F-2-isoP levels in numerous studies, whereas trans-fatty acids raised F-2-isoP excretion. Yet, the reported heterogeneous results reveal important considerations, such as the health status of the participants, the biological fluids used to determine F-2-isoP, the analytical methods employed and the specific F-2-isoP isomers detected. Therefore, future clinical studies should be designed in order to consider these issues in the studies of the effects of fat intake on oxidative stress.
机译：证据支持高膳食脂肪摄入增加氧化应激和饮食诱发的代谢障碍，如肥胖，糖尿病和心血管疾病。 F-2-异戊烷（F-2-ISOP）由花生酸的非酶促氧化形成，并且广泛应用于临床研究中的氧化胁迫的可靠生物标志物。膳食脂肪可能影响F-2-ISOP水平，因为它们（1）是它们的形成代谢底物，（2）改变组织的脂质组合物，（3）影响涉及F-2的血浆脂蛋白浓度ISOP运输。该综述检测了关于膳食脂肪如何影响患有健康或恶化的代谢型材的个体中F2-ISOP的血液循环和排泄的最新临床证据。临床研究报告说，饱和或单不饱和脂肪的饮食不会影响成人的F-2-ISOP水平，其具有健康或恶化的代谢谱。虽然，Omega-3多不饱和脂肪酸在许多研究中降低了F-2-ISOP水平，而转脂酸升高了F-2-ISOP排泄。然而，报告的异质结果揭示了重要的考虑因素，例如参与者的健康状况，用于确定F-2-ISOP的生物流体，采用的分析方法和检测到的特定F-2-ISOM异构体。因此，应设计未来的临床研究，以便考虑脂肪摄入对氧化应激的影响的研究。

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