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首页> 外文期刊>Critical reviews in oncology/hematology >Current perspectives on the crosstalk between lung cancer stem cells and cancer-associated fibroblasts
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Current perspectives on the crosstalk between lung cancer stem cells and cancer-associated fibroblasts

机译：目前对肺癌干细胞和癌症相关成纤维细胞之间的串扰的目前的观点

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Lung cancer, in particular non-small cell lung carcinoma (NSCLC), is the second most common cancer in both men and women and the leading cause of cancer-related deaths worldwide. Its prognosis and diagnosis are determined by several driver mutations and diverse risk factors (e.g. smoking). While immunotherapy has proven effective in some patients, treatment of NSCLC using conventional chemotherapy is largely ineffective. The latter is believed to be due to the existence of a subpopulation of stem-like, highly tumorigenic and chemoresistant cells within the tumor population known as cancer stem cells (CSC). To complicate the situation, CSCs interact with the tumor microenvironment, which include cancer-associated fibroblasts (CAFs), immune cells, endothelial cells, growth factors, cytokines and connective tissue components, which via a dynamic crosstalk, composed of proteins and exosomes, activates the CSC compartment. In this review, we analyze the crosstalk between CSCs and CAFs, the primary component of the NSCLC microenvironment, at the molecular and extracellular level and contemplate therapies to disrupt this communication.
机译：肺癌，特别是非小细胞肺癌（NSCLC），是男性和妇女的第二次常见的癌症以及全世界癌症相关死亡的主要原因。其预后和诊断由几种驾驶员突变和多种风险因素（例如吸烟）决定。虽然在某些患者中证明免疫疗法有效，但使用常规化疗的NSCLC治疗主要是无效的。后者被认为是由于存在于称为癌症干细胞（CSC）的肿瘤群体内的干草状，高度致瘤和化学浓缩细胞的亚群。使情况复杂化，CSCs与肿瘤微环境相互作用，该肿瘤微环境包括癌症相关的成纤维细胞（CAF），免疫细胞，内皮细胞，生长因子，细胞因子和结缔组织组分，其通过动态串扰，由蛋白质和外泌体组成，激活CSC隔间。在本综述中，我们在分子和细胞外水平下分析CSC和CAF之间的串扰，NSCLC微环境的主要成分，并考虑疗法以破坏这种通信。

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