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Exploring the role of programmed cell death protein 1 and its ligand 1 in eve diseases

机译：探索程序化细胞死亡蛋白1及其配体1在eve疾病中的作用

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摘要

Programmed death receptor-1 (PD-1) and its ligand, PD-L1, as negative co-stimulatory molecules, are indispensable for regulating both physiological and pathological immune responses. The PD-1 /PD-L1 -mediated signaling pathway has been studied extensively in cancer research and has become a hotspot for biopharmaceuticals and immunotherapy. Furthermore, monoclonal antibodies to PD-1 have just been approved by the US Food and Drug Administration to treat certain types of malignancies. Recent research has unveiled a close association between the PD-1/PD-L1 system and eye diseases. This review describes the expression and physiological functions of PD-1 and its ligand in ocular tissues and summarizes the pathogenic, regulatory, and therapeutic roles of PD-1/PD-L1 system in eye diseases, including uveal melanoma, autoimmune uveitis, autoimmune dry eye, sympathetic ophthalmia, Graves' ophthalmopathy, diabetic retinopathy, herpes simplex keratitis, and trachoma, with the intent of highlighting the potential of PD-1/PD-L1 as novel therapeutic targets or biomarkers for these ocular, diseases.
机译：编程死亡受体-1（PD-1）及其配体PD-L1作为阴性共刺激分子是不可或缺的，用于调节生理和病理免疫应答。 PD-1 / PD-L1介导的信号通路已经过度研究癌症研究，并已成为生物制药和免疫疗法的热点。此外，对PD-1的单克隆抗体刚被美国食品和药物管理局批准，以治疗某些类型的恶性肿瘤。最近的研究推出了PD-1 / PD-L1系统和眼部疾病之间的紧密关联。该综述描述了PD-1及其配体在眼组织中的表达和生理功能，并总结了PD-1 / PD-L1系统在眼部疾病中的病原，调节和治疗作用，包括过肺黑素瘤，自身免疫葡萄质炎，自身免疫干燥眼睛，交感神经眼科，Graves的眼科病，糖尿病视网膜病变，单纯疱疹性角膜炎和沙眼，意图突出显示PD-1 / PD-L1作为这些眼部，疾病的新治疗靶或生物标志物。

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