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首页> 外文期刊>Critical reviews in clinical laboratory sciences >Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy
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Activation of sphingosine-1-phosphate signalling as a potential underlying mechanism of the pleiotropic effects of statin therapy

机译：鞘氨氨酸-1-磷酸磷酸磷酸磷酸磷酸磷酸术的激活作为肠疗法的抗性效应的潜在基础机制

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The mechanisms by which statins are beneficial are incompletely understood. While the lowering of low-density lipoprotein concentration is associated with regression of atherosclerosis, the observed benefit of statin therapy begins within months after its initiation, making regression an unlikely cause. Although LDL-C lowering is the main mechanism by which statin therapy reduces cardiovascular events, evidence suggests that at least some of the beneficial actions of statins may be mediated by their pleiotropic effects. Thus, statins may modulate the function of cardiovascular cells and key signalling proteins, including small G-proteins, to ultimately exert their pleiotropic effects. Sphingosine-1-phosphate (SI P) is a naturally occurring bioactive lysophospholipid that regulates diverse physiological functions in a variety of different organ systems. Within the cardiovascular system, SIP mediates cardioprotection following ischemia/reperfusion injury, anti-inflammatory response, improvement of endothelial function, increased mobilization and differentiation of endothelial progenitor cells, inhibition of oxidation, and anti-atherogenic and anti-thrombotic actions. Early evidence suggests that the pleiotropic effects of statins may be related to an increase in S1P signalling. This review focuses on SIP signalling as the potential mechanism underlying the pleiotropic effects of statins. An improved understanding of this mechanism may be vital for establishing the clinical relevance of statins and their importance in the treatment and prevention of coronary artery disease.
机译：他汀类药物是有益的机制是不完全理解的。虽然低密度脂蛋白浓度的降低与动脉粥样硬化的回归有关，但观察到的他汀类药物治疗的益处在其开始后的几个月内始于，使回归成为不太可能的原因。虽然LDL-C降低是他汀类药物治疗减少心血管事件的主要机制，但证据表明，至少一些他汀类药物的有益作用可以通过它们的血流效应介导。因此，他汀类药物可以调节心血管细胞的功能和包括小G-蛋白的关键信号传导蛋白，最终施加抗血液效应。鞘氨氨酸-1-磷酸（Si P）是一种天然存在的生物活性溶血磷脂，可调节各种不同器官系统中的各种生理功能。在心血管系统内，SIP介导心脏保护术后缺血/再灌注损伤，抗炎反应，内皮功能的提高，内皮祖细胞的动员增加，抑制氧化，抗动脉粥样硬化和抗血栓形成动作。早期证据表明，他汀类药物的脂肪效应可能与S1P信号传导的增加有关。本综述重点介绍SIP信令作为他汀类药物润滑效应的潜在机制。改善对这种机制的理解可能对于建立他汀类药物的临床相关性以及它们在治疗和预防冠状动脉疾病中的重要性至关重要。

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