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首页> 外文期刊>Cornea >Examining the Impact of Corneal Tissue Transnational Activity, and Transplantation, on Import and Export Nations: A Review of the Literature
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Examining the Impact of Corneal Tissue Transnational Activity, and Transplantation, on Import and Export Nations: A Review of the Literature

机译：检查角膜组织跨国活动的影响，移植，进出口国家：文献述评

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Purpose: Globally, an estimated 12.7 million people await a corneal transplant. Of these, 53% are without routine access to a domestic supply and are reliant on transnational activity (TNA) (importation) of corneal tissue (CT) for transplantation. Although CT TNA commenced in 1961, there has been no evaluation of its impact on import and export nations. Methods: We wished to examine the impact of clinical and nonclinical CT TNA on export and import nations, with nonclinical aspects our primary focus, to help guide future practice. We conducted a review of the academic literature through various search engines. We prefix and place our review in the relevant historical practice and global context. Results: Despite commencement in 1961, we only located 14 studies (11 clinical and 3 nonclinical) pertaining to CT TNA. These were published between 1991 and 2018. Clinical papers reported death-to-preservation time, preservation-to-transplantation time, logistics, donor and recipient selection, and quality as relevant. Nonclinical studies identified emerging themes pertaining to financial, ethical, and sustainability aspects of TNA. Conclusions: All aspects of CT TNA are grossly under-reported, resulting in our inability to effectively analyze the overall impact to export and import nations. The few clinical studies in our review concluded that despite endothelial cell loss and other risk factors, imported CT appears comparable with domestic CT and remains an option in the absence of domestic supply. Nonclinical aspects (eg, ethical, equitable, and economic) have also not been adequately addressed.
机译：目的：在全球范围内，估计为1270万人等待角膜移植。其中，53％没有常规访问国内供应，并依赖于角膜组织（CT）的跨国活性（进口）进行移植。虽然CT TNA于1961年开始，但没有评估其对进出口国家的影响。方法：我们希望审查临床和非临床CT TNA对出口和进口国家的影响，我们的主要重点是非界面的关注，帮助指导未来的惯例。我们通过各种搜索引擎对学术文献进行了审查。我们在相关的历史实践和全球背景下向我们进行前缀并将审核。结果：尽管1961年开始，我们只定位了与CT TNA有关的14项研究（11个临床和3个非临床）。这些发表于1991年至2018年。临床论文报告了保存的死亡时间，保存到移植时间，物流，捐助者和受体选择，以及质量与相关。非铭文研究确定了与TNA的财务，道德和可持续性方面有关的新兴主题。结论：CT TNA的各个方面都报告了严重的报道，导致我们无法有效分析出口和进口国家的整体影响。我们评论中的少数临床研究得出结论，尽管内皮细胞丧失和其他危险因素，但进口的CT与国内CT看起来可与缺乏国内供应的选择。非临界方面（例如，道德，公平和经济）也没有得到充分解决。

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