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首页> 外文期刊>Cornea >Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis.
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Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis.

机译：多中心开放标签研究评估阿奇霉素眼科溶液的疗效1％对具有睑淋巴炎的受试者的迹象和症状。

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PURPOSE: To evaluate the effect of 4 weeks of treatment with azithromycin ophthalmic solution 1% on eyelid bacterial load, tear cytokines, and signs and symptoms of blepharitis. METHODS: Twenty-six subjects (mean age 64.2 years; 65% female; 100% white) with moderate to severe blepharitis received azithromycin ophthalmic solution 1% in the absence of warm compresses or eyelid scrubs for 28 days (twice a day on days 1 and 2 and once a day on days 3-28). Blepharitis signs and symptoms were evaluated at baseline (day 1) and compared with end of treatment (day 29) and 2 follow-up visits (2 and 4 weeks posttreatment). Tear collection and eyelid margin bacterial cultures were performed at baseline and end of treatment. Tear cytokines were measured by a multiplex immunobead assay. RESULTS: Four-week azithromycin treatment demonstrated significant decreases from baseline in investigator-rated signs of meibomian gland plugging, eyelid margin redness, palpebral conjunctival redness, and ocular discharge (P < or = 0.002) at day 29, which persisted 4 weeks posttreatment (P < or = 0.006). Subject-reported symptoms of eyelid itching, foreign body sensation/sandiness/grittiness, ocular dryness, ocular burning/pain, and swollen/heavy eyelids also demonstrated significant improvement from baseline (P < 0.001 for all symptoms and time points, except P = 0.037 for ocular dryness at visit 4). Eyelid margin culture exhibited significant decreases in coagulase-negative staphylococci and Corynebacterium xerosis bacteria. Changes in tear cytokine concentrations were not observed. Twelve subjects experienced 19 adverse events, 15 of which were ocular and none of which were serious. CONCLUSIONS: Azithromycin provided significant improvement in signs and symptoms of blepharitis after 4 weeks of treatment compared with baseline and persisted in the 4-week follow-up period.
机译：目的：评估4周治疗与氮霉素眼科溶液的效果1％对眼睑细菌载荷，撕裂细胞因子以及睑缘炎的迹象和症状。方法：二十六个受试者（平均年龄64.2岁; 65％的女性; 100％白色），中度至严重的睑炎接受了氮霉素眼科溶液1％在没有温热的压缩或眼睑擦洗28天（每天两次和2和第3-28天的每天一次）。在基线（第1天）评估了睑炎症状和症状，与治疗结束（第29天）和2个后续访问（2和4周后2周）进行比较。在基线和治疗结束时进行撕裂收集和眼睑裕度细菌培养物。通过多重免疫形式测定法测量泪液细胞因子。结果：四周氮杂霉素治疗表明，在第29天的第29天持续4周的第29天（ p <或= 0.006）。报告的眼睑瘙痒症状，异物感觉/砂质/砂砾，眼睛干燥，眼睑灼热/疼痛以及肿胀/重眼睑也表现出从基线显着改善（所有症状和时间点P <0.001，除p = 0.037访问4）的眼睛干燥。眼睑保证金文化在凝结酶阴性葡萄球菌和棒状杆菌细菌中表现出显着降低。未观察到撕裂细胞因子浓度的变化。 12个受试者经历了19个不良事件，其中15个是眼睑，其中没有一个严重。结论：阿奇霉素在治疗4周后，与基线相比，在治疗4周后提供了显着改善，并在4周随访期间持续存在。

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