In vitro Methods for In vitro-In vivo Correlation (IVIVC) for Poorly Water Soluble Drugs: Lipid Based Formulation Perspective

Kazi Mohsin; Al Amri Rayan; Alanazi Fars K.; Hussain Muhammad Delwar

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In vitro Methods for In vitro-In vivo Correlation (IVIVC) for Poorly Water Soluble Drugs: Lipid Based Formulation Perspective

机译：用于差的水溶性药物（IVIVC）的体外方法的体外方法：脂质的制剂观点

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A great number of new drug candidates identified from the discovery pipeline are poorly water soluble, which is a drawback to bring such candidates into the pharmaceutical market. Formulating these compounds as self-emulsifying/microemulsifying/nanoemulsifying drug delivery systems (SEDDS/SMEDDS/SNEDDS) within lipid based formulations is of growing interest. Some of the recent studies have resulted in commercial products that provided improved bioavailability and dissolution due to the better dispersion properties of SEDDS/SMEDDS/SNEDDS. An ongoing challenge that the pharmaceutical industry is facing is identifying in vitro tests that are needed in order to predict the behavior of dosage forms in the GI tract. The goal of the current review is to present the various levels of in vitro-in vivo correlations (IVIVCs) and to provide tools on the utilization of the IVIVCs in product development and optimization of SEDDS/SMEDDS/SNEDDS.

机译：从发现管道确定的大量新药物候选者是可靠的差，这是将这种候选人带入制药市场的缺点。将这些化合物作为自乳化/微乳化/纳米乳化药物递送系统（SEDDS / SMEDDS / SNEDDS）在脂质的制剂中具有越来越感兴趣。最近的一些研究导致商业产品提供了改善的生物利用度和溶解，因为潜水/ SMEDDS / SNEDDS的更好分散性能。持续的挑战，制药行业面临的是鉴定需要进行的体外试验，以预测GI在GI道中的剂型形式的行为。目前审查的目的是呈现各种水平的体外相关（IVIVC），并提供有关在产品开发和优化潜水/ SMEDDS / SNEDDS中的IVIVC的工具。

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来源
《Current drug delivery》 |2018年第7期|共12页
作者
Kazi Mohsin; Al Amri Rayan; Alanazi Fars K.; Hussain Muhammad Delwar;
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作者单位

King Saud Univ Coll Pharm Kayyali Chair Pharmaceut Ind Riyadh 11451 Saudi Arabia;

King Saud Univ Coll Pharm Kayyali Chair Pharmaceut Ind Riyadh 11451 Saudi Arabia;

King Saud Univ Coll Pharm Kayyali Chair Pharmaceut Ind Riyadh 11451 Saudi Arabia;

Calif Hlth Sci Univ Coll Pharm Dept Pharmaceut &

Biomed Sci Clovis CA 93612 USA;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Lipid based formulation; SEDDS/SMEDDS/SNEDDS; poorly water soluble drugs; dissolution; lipolysis; IVIVC;

机译：基于脂质的配方;潜水/中小型/鼻涕;水溶性差的药物;溶解;脂解;IVIVC;

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1. In vitro Methods for In vitro-In vivo Correlation (IVIVC) for Poorly Water Soluble Drugs: Lipid Based Formulation Perspective [J] . Kazi Mohsin, Al Amri Rayan, Alanazi Fars K., Current drug delivery . 2018,第7期

机译：用于差的水溶性药物（IVIVC）的体外方法的体外方法：脂质的制剂观点
2. Computer-based evolutionary search for a nonlinear conversion function for establishing in vitro-in vivo correlation (IVIVC) of oral drug formulations [J] . YamashitaF., FujitaA., ZhangX., Drug metabolism and pharmacokinetics. . 2012,第3期

机译：基于计算机的进化搜索，用于建立口服药物制剂的体外-体内相关性（IVIVC）的非线性转换函数
3. Use of In Vitro-In Vivo Correlation (IVIVC) to Facilitate the Development of Polymer-Based Controlled Release Injectable Formulations [J] . Amitava Mitra Yunhui Wu Recent Patents on Drug Delivery & Formulation . 2010,第2期

机译：使用体内体外相关性（IVIVC）来促进基于聚合物的控释注射剂的开发
4. In-vitro Testing to Select Type IV Lipid-Based Formulations Encapsulated in Capsule Drug Delivery Systems for in-vivo Studies [C] . Annual meeting exposition of the Controlled Release Society . 2009

机译：在体外测试中选择型IV型脂质的配方包封在胶囊药物递送系统中，用于体内研究
5. Nanoparticle Formulations of Poorly Water Soluble Drugs and Their Action In Vivo and In Vitro. [D] . Purvis, Troy Powell. 2007

机译：水溶性差的药物的纳米颗粒制剂及其体内和体外作用。
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7. Formulation and Evaluation of RSM Based Floating Alginate Microspheres of Gymnemic Acid In Vitro-In Vivo Correlation (IVIVC) for Treatment of Diabetes Mellitus [O] . Mr. Debraj De, Dr. Rabindranath Pal 2019

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In vitro Methods for In vitro-In vivo Correlation (IVIVC) for Poorly Water Soluble Drugs: Lipid Based Formulation Perspective

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