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首页> 外文期刊>Acta Biochimica Polonica >The genetic polymorphism in the STK11 does not affect gestational diabetes
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The genetic polymorphism in the STK11 does not affect gestational diabetes

机译：STK11中的基因多态性不影响妊娠糖尿病

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Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance of variable severity that develops during pregnancy. Recent studies indicate that GDM onset is rapid, and that women with GDM will develop other metabolic disorders such as obesity, type 2 diabetes, and cardiovascular disease in their future. Serine/threonine kinase 11 (STK11) is engaged in the insulin signaling pathway and encoded protein is an important activator of adenosine monophosphate activated protein kinase. Based on the previously reported association between the STK11 gene and diabetes, we aimed to investigate whether the rs8111699 polymorphism in STK11 has any role in gestation diabetes in Saudi women. In this case-control study, we recruited pregnant Saudi women based on biochemical analysis of their blood samples. Genomic DNA was obtained from confirmed subjects (200 GDM cases and 300 non-GDM). PCR-RFLP analysis was performed to detect the C528G polymorphism in the STK11 gene. The anthropometric and clinical data were similar between the GDM and non-GDM subjects (p>0.05), whereas the biochemical analysis was significantly different between the cases and controls (p<0.05). The genotype and allele frequencies between of the STK11 gene were not statistically significant difference between the GDM and non-GDM groups (OR=0.82; 95% CI:=0.6-1.0; p=0.12). Our study suggests that the rs8111699 polymorphism has no role in the development of GDM in pregnant Saudi women.
机译：妊娠期糖尿病（GDM）被定义为在怀孕期间发生的严重程度不同的碳水化合物不耐症。最近的研究表明，GDM起病迅速，患有GDM的妇女将来还会发展其他代谢性疾病，例如肥胖，2型糖尿病和心血管疾病。丝氨酸/苏氨酸激酶11（STK11）参与胰岛素信号传导途径，编码的蛋白是单磷酸腺苷激活的蛋白激酶的重要激活剂。基于先前报道的STK11基因与糖尿病之间的关联，我们旨在研究STK11中的rs8111699多态性在沙特女性的妊娠糖尿病中是否有作用。在此病例对照研究中，我们根据对沙特阿拉伯孕妇的血液样本进行生化分析，招募了这些孕妇。从确诊的受试者（200个GDM病例和300个非GDM病例）获得基因组DNA。进行PCR-RFLP分析以检测STK11基因中的C528G多态性。 GDM和非GDM受试者的人体测量学和临床数据相似（p> 0.05），而病例和对照之间的生化分析显着不同（p <0.05）。 STK11基因之间的基因型和等位基因频率在GDM组和非GDM组之间无统计学差异（OR = 0.82; 95％CI：= 0.6-1.0; p = 0.12）。我们的研究表明，rs8111699基因多态性在孕妇沙特妇女的GDM发育中没有作用。

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