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首页> 外文期刊>Acta Biochimica Polonica >Splenic melanosis in agouti and black mice
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Splenic melanosis in agouti and black mice

机译：刺鼠和黑鼠的脾脏黑色素病

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摘要

An interesting example of extradermal deposition of melanin in vertebrates, notably in mammals, is splenic melanosis. In particular, if the phenomenon of splenic melanosis is correlated with hair or skin pigmentation, it must reflect the amount and perhaps the quality of pigment produced in hair follicle melanocytes. The present paper is our first study on splenic pigmentation in mice of phenotype agouti. We used untreated mixed background mice C57BL/6; 129/SvJ (black - a/a, agouti - A/a, A/A), and as a control - black C57BL/6 and agouti fur from 129/SvJ mice, Mongolian gerbils (Meriones unguiculatus) and golden hamsters (Mesocricetus auratus). After euthanasia skin and spleen was evaluated macroscopically, photographed and collected for further analysis using Fontana-Masson and hematoxylin-eosin staining and electron paramagnetic resonance (EPR) at X-band. Spleens of the agouti mice revealed splenic melanosis but were slightly weaker pigmented than their black counterparts, while the presence of pheomelanin was difficult to determine. The fur of both phenotypes was of similar melanin content, with the same tendency as in the spleens. The contribution of pheomelanin in the agouti fur was on the border of detectability by EPR. Histological and EPR analysis confirmed the presence of melanin in the melanotic spleens. The shape of the EPR signal showed a dominance of eumelanin in fur and in melanized spleens in both phenotypes of mice. Therefore, splenic melanosis does reflect the hair follicle pigmentation not only in black, but also in agouti mice.
机译：在脊椎动物中，尤其是在哺乳动物中，黑色素的真皮外沉积的一个有趣例子是脾脏黑色素病。特别是，如果脾脏黑色素化现象与头发或皮肤色素沉着有关，则它必须反映出毛囊黑素细胞中产生的色素的数量和质量。本文是我们对表型刺豚鼠脾脏色素沉着的首次研究。我们使用未经处理的混合背景小鼠C57BL / 6; 129 / SvJ（黑色-a / a，刺豚鼠-A / a，A / A），作为对照-来自129 / SvJ小鼠，蒙古沙鼠（Meriones unguiculatus）和金色仓鼠（Mesocricetus）的黑色C57BL / 6和刺豚草皮光环）。安乐死后，对皮肤和脾脏进行宏观评估，拍照并收集，以使用Fontana-Masson和苏木精-伊红染色和X波段电子顺磁共振（EPR）进行进一步分析。刺鼠的脾脏显示出脾脏黑色素沉着症，但其色素沉着较其黑色黑鼠稍弱，而难以确定是否存在pheomelanin。两种表型的皮毛具有相似的黑色素含量，与脾脏中的趋势相同。苯丙氨酸在刺豚鼠皮毛中的贡献处于EPR可检测性的边缘。组织学和EPR分析证实黑色素脾脏中存在黑色素。 EPR信号的形状在两种表型的小鼠的皮毛和黑色素化的脾脏中均显示了Eumelanin的优势。因此，脾脏黑变不仅反映了黑色的毛囊色素沉着，而且也反映了刺鼠的毛囊色素沉着。

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