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Epigenetic regulation of adipogenesis

机译：表观遗传调节脂肪生成

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Purpose of review: Epigenetic regulation plays an essential role in cell differentiation, by allowing the establishment and maintenance of the gene-expression pattern of the mature cell type. Because of its importance in chronic diseases, adipogenesis is one of the best-studied differentiation processes. The hormonal and transcriptional cascades governing the differentiation of the adipocytes are well known, but the role of epigenetic mechanisms is only starting to emerge. In this review, we intend to summarize the recently described epigenetic events that participate in adipogenesis and their connections with the main factors that constitute the classical transcriptional cascade. Recent findings: The advent of high-throughput technologies has made possible the exhaustive analysis of the epigenetic phenomenons taking place during adipogenesis. The cooperative recruitment of CCAAT/enhancer-binding protein (C/EBPβ) and other early proadipogenic transcription factors to transcription factor hotspots shortly after induction of adipogenesis is required to establish a transient epigenomic state that then informs the recruitment of the later adipogenic transcription factors peroxisome proliferator-activated receptor (PPARγ) and C/EBPα to their target genes. Summary: Epigenetic marks and chromatin-modifying proteins contribute to adipogenesis and, through regulation of the phenotypic maintenance of the mature adipocytes, to the control of metabolism.
机译：审查目的：表观遗传调节通过允许建立和维持成熟细胞类型的基因表达模式，在细胞分化中起重要作用。由于其对慢性病的重要性，脂肪生成是最佳研究的分化过程之一。治疗脂肪细胞分化的激素和转录级联是众所周知的，但表观遗传机制的作用只是开始出现。在这篇综述中，我们打算总结最近描述的表观遗传事件，其参与脂肪发生及其与构成典型转录级联的主要因素的联系。最近的调查结果：高通量技术的出现使得在脂肪生成期间发生的表观遗传现象的详尽分析。需要在诱导脂肪发生诱导后不久的CCAAT /增强剂结合蛋白（C /EBPβ）和其他早期促潜转录因子的合作募集，以建立瞬态表观态调节，然后通知促进过氧化物的后期脂肪转录因子增殖剂活化受体（PPARγ）和C /EBPα对其靶基因。发明内容：表观遗传标记和染色质 - 改性蛋白有助于脂肪发生，通过调节成熟脂肪细胞的表型维持，对代谢的控制。

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