• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?
【24h】

Butyrate and other short-chain fatty acids as modulators of immunity: what relevance for health?

机译：丁酸盐和其他短链脂肪酸作为免疫调节剂：对健康有什么相关性？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE OF REVIEW: High-fiber diets have been shown to reduce plasma concentrations of inflammation markers. Increased production of fermentation-derived short-chain fatty acids (SCFAs) is one of the factors that could exert these positive effects. This review examines the effects of SCFAs on immune cells and discusses the relevance of their effects on systemic inflammation, as frequently seen in obesity. RECENT FINDINGS: SCFAs have been shown to reduce chemotaxis and cell adhesion; this effect is dependent on type and concentration of SCFA. In spite of conflicting results, especially butyrate seems to have an anti-inflammatory effect, mediated by signaling pathways like nuclear factor-kappaB and inhibition of histone deacetylase. The discrepancies in the results could be explained by differences in cell types used and their proliferative and differentiation status. SUMMARY: SCFAs show anti-inflammatory effects and seem to have the potency to prevent infiltration of immune cells from the bloodstream in, for example, the adipose tissue. In addition, their ability to inhibit the proliferation and activation of T cells and to prevent adhesion of antigen-presenting cells could be important as it recently has been shown that obesity-associated inflammation might be antigen-dependent. More studies with concentrations in micromolar range are needed to approach more physiological concentrations.
机译：审查目的：已显示高纤维饮食以降低血浆浓度的炎症标志物。增加发酵衍生的短链脂肪酸（SCFA）是可以发挥这些积极效应的因素之一。本综述研究了SCFA对免疫细胞对免疫细胞的影响，并讨论了它们对肥胖症中经常出现的对系统性炎症的影响。最近的发现：已显示SCFA可降低趋化性和细胞粘附;这种效果取决于SCFA的类型和浓度。尽管结果相互矛盾，但特别是丁酸盐似乎具有抗炎作用，通过核因子-κB等信号传导途径和组蛋白脱乙酰酶的抑制介导。结果的差异可以通过所使用的细胞类型和增殖和分化状态的差异来解释。发明内容：SCFA显示出抗炎作用，似乎有效力，以防止免疫细胞从例如脂肪组织中的血液中的免疫细胞渗透。此外，它们抑制T细胞增殖和激活并防止抗原呈递细胞的粘附能力可能是重要的，因为最近已经表明肥胖相关的炎症可能是抗原依赖性。需要在微摩尔范围内的浓度进行更多的研究来接近更具生理浓度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号