Neural lineage tracing in the mammalian brain

Jian Ma; Zhongfu Shen; Yong-Chun Yu; Song-Hai Shi

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Neural lineage tracing in the mammalian brain

机译：哺乳动物大脑中的神经谱系追踪

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Delineating the lineage of neural cells that captures the progressive steps in their specification is fundamental to understanding brain development, organization, and function. Since the earliest days of embryology, lineage questions have been addressed with methods of increasing specificity, capacity, and resolution. Yet, a full realization of individual cell lineages remains challenging for complex systems. A recent explosion of technical advances in genome-editing and single-cell sequencing has enabled lineage analysis in an unprecedented scale, speed, and depth across different species. In this review, we discuss the application of available as well as future genetic labeling techniques for tracking neural lineagesin vivoin the mammalian nervous system.

机译：描绘神经细胞的谱系，以捕捉其规范中的渐进步骤是了解大脑发展，组织和功能的基础。自胚胎学最早的日期以来，已经通过增加特异性，容量和决议的方法来解决逻辑问题。然而，对复杂系统的全面实现对各个细胞谱系仍然具有挑战性。最近关于基因组编辑和单细胞测序的技术进步的爆发使沿着不同物种的前所未有的规模，速度和深度能够使谱系分析能够使谱系分析能够。在这篇综述中，我们讨论了可用的应用以及未来的遗传标记技术，用于跟踪哺乳动物神经系统的神经阵列。

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《Current Opinion in Neurobiology》 |2018年第2018期|共10页
作者
Jian Ma; Zhongfu Shen; Yong-Chun Yu; Song-Hai Shi;
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作者单位

Tsinghua-Peking Center for Life Sciences IDG/McGovern Institute for Brain Research School of Life;

Tsinghua-Peking Center for Life Sciences IDG/McGovern Institute for Brain Research School of Life;

Institute of Brain Science State Key Laboratory of Medical Neurobiology and Collaborative;

Developmental Biology Program Sloan Kettering Institute Memorial Sloan Kettering Cancer Center;

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正文语种 eng
中图分类神经病学;
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1. Neural lineage tracing in the mammalian brain [J] . Jian Ma, Zhongfu Shen, Yong-Chun Yu, Current Opinion in Neurobiology . 2018,第期

机译：哺乳动物大脑中的神经谱系追踪
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4. How transcriptional and epigenetic programmes are played out on an individual mammalian gene cluster during lineage commitment and differentiation [C] . Douglas R.Higgs, Douglas Vernimmen, Marco De Gobbi Biochemical Society Symposium . 2006

机译：在血统承诺和分化期间，如何在个体哺乳动物基因集群上进行转录和表观遗传程序。
5. Analysis of the Neural and Glial Lineages Establishing the Cytoarchitecure of the Drosophila melanogaster Central Brain. [D] . Omoto, Jaison Jiro. 2017

机译：分析神经和神经胶质谱系，建立果蝇中脑的细胞结构。
6. Neural lineage tracing in the mammalian brain [O] . Jian Ma, Zhongfu Shen, Yong-Chun Yu, -1

机译：哺乳动物大脑中的神经谱系追踪
7. Neural lineage tracing in the mammalian brain [O] . Jian Ma, Zhongfu Shen, Yong-Chun Yu, 2018

机译：哺乳动物大脑中的神经谱系追踪

Neural lineage tracing in the mammalian brain

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