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Development of vestibular behaviors in zebrafish

机译:在斑马鱼中发展前庭行为

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摘要

Most animals orient their bodies with respect to gravity to facilitate locomotion and perception. The neural circuits responsible for these orienting movements have long served as a model to address fundamental questions in systems neuroscience. Though postural control is vital, we know little about development of either balance reflexes or the neural circuitry that produces them. Recent work in a genetically and optically accessible vertebrate, the larval zebrafish, has begun to reveal the mechanisms by which such vestibular behaviors and circuits come to function. Here we highlight recent work that leverages the particular advantages of the larval zebrafish to illuminate mechanisms of postural development, the role of sensation for balance circuit development, and the organization of developing vestibular circuits. Further, we frame open questions regarding the developmental mechanisms for functional circuit assembly and maturation where studying the zebrafish vestibular system is likely to open new frontiers.
机译:大多数动物相对于重力定向身体,以促进运动和感知。负责这些定向运动的神经电路长期以来,作为一种模型,可以解决系统神经科学中的基本问题。虽然姿势控制是至关重要的,但我们很少了解余额反射的发展或产生它们的神经电路。最近在遗传和光学访问的脊椎动物中的工作,幼虫斑马鱼已经开始揭示这种前庭行为和电路功能的机制。在这里,我们突出了最近的工作,利用幼虫斑马鱼的特殊优势来照亮姿势发展的机制,平衡电路开发的感觉的作用,以及开发前庭电路的组织。此外,我们框架有关功能电路组件和成熟的开发机制的开放问题,其中研究斑马鱼前庭系统可能开辟新的边界。

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