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首页> 外文期刊>Current Opinion in Neurobiology >Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity
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Astrocyte identity: evolutionary perspectives on astrocyte functions and heterogeneity

机译:星形胶质细胞同一性:对星形胶质细胞功能和异质性的进化视角

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摘要

The development of new animal models, in vivo isolation approaches, and improvements in genome-wide RNA expression methods have greatly propelled molecular profiling of astrocytes and the characterization of astrocyte heterogeneity in the central nervous system (CNS). Several recent reviews have comprehensively discussed the molecular and functional diversity of mammalian astrocytes. In this brief review, we emphasize interspecies comparisons and an evolutionary perspective regarding the astro(glia) of vertebrates and invertebrates which are similar in form and function. This analysis has revealed conserved astrocyte transcriptomes in the fly, mouse and human. We also offer opinions about the pattern and origin of astrocyte heterogeneity in the CNS.
机译:在体内隔离方法和基因组RNA表达方法中的新动物模型的发展具有大大推进了星形胶质细胞的分子分析,并在中枢神经系统(CNS)中的星形胶质细胞异质性的表征。 近几次评论综合地讨论了哺乳动物星形胶质细胞的分子和功能多样性。 在这篇简短的综述中,我们强调了脊椎动物和无脊椎动物的Astro(Glia)的梭坡比较和进化的视角,其形式和功能类似。 这种分析揭示了苍蝇,小鼠和人的过度的星形胶质细胞转录om。 我们还提出了关于CNS中星形胶质细胞异质性的模式和起源的意见。

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