Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer

Middleton Gary; Gridelli Cesare; De Marinis Filippo; Pujol Jean-Louis; Reck Martin; Ramlau Rodryg; Parente Barbara; Pieters Thierry; Visseren-Grul Carla M.; San Antonio Belen; John William J.; Zimmermann Annamaria Hayden; Chouaki Nadia; Paz-Ares Luis

首页> 外文期刊>Current medical research and opinion >Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer

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Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer

机译：评估临情中肾功能变化的评价：A第III期维修PEMORTEXED加上最佳支持性护理与PEMORTEXED加顺铂治疗高级非小细胞肺癌诱导治疗后的最佳支持性护理

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Objectives: To assess the effect of long-term pemetrexed maintenance therapy on patients' renal function.

机译：目的：评估长期培养维持治疗对患者肾功能的影响。

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来源
《Current medical research and opinion》 |2018年第5期|共7页
作者
Middleton Gary; Gridelli Cesare; De Marinis Filippo; Pujol Jean-Louis; Reck Martin; Ramlau Rodryg; Parente Barbara; Pieters Thierry; Visseren-Grul Carla M.; San Antonio Belen; John William J.; Zimmermann Annamaria Hayden; Chouaki Nadia; Paz-Ares Luis;
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作者单位

Univ Birmingham Birmingham W Midlands England;

San Giuseppe Moscati Hosp Avellino Italy;

European Inst Oncol Milan Italy;

CHRU Montpellier Montpellier France;

German Ctr Lung Res DZL ARCN LungenClin Grosshansdorf Dept Thorac Oncol Grosshansdorf Germany;

Poznan Univ Med Sci Poznan Poland;

Hosp CUF Porto Porto Portugal;

Catholic Univ Louvain Clin Univ St Luc Brussels Belgium;

Eli Lilly &

Co Houten Netherlands;

Eli Lilly &

Co Madrid Spain;

Eli Lilly &

Co Indianapolis IN 46285 USA;

Eli Lilly &

Co Indianapolis IN 46285 USA;

Eli Lilly &

Co Paris France;

Univ Seville Univ Hosp Virgen del Rocio IBIS Seville Spain;

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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
Creatinine clearance; maintenance therapy; non-small-cell-lung cancer; pemetrexed; serum creatinine; renal toxicity;

机译：肌酐清除;维持治疗;非小细胞肺癌;培养基;培养基;血清肌酐;肾毒性;

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1. Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer [J] . Middleton Gary, Gridelli Cesare, De Marinis Filippo, Current medical research and opinion . 2018,第5期

机译：评估临情中肾功能变化的评价：A第III期维修PEMORTEXED加上最佳支持性护理与PEMORTEXED加顺铂治疗高级非小细胞肺癌诱导治疗后的最佳支持性护理
2. Treatment rationale and study design for a phase III, double-blind, placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer [J] . Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, BMC Cancer . 2010,第1期

机译：培美曲塞加顺铂诱导治疗晚期非鳞状非小细胞肺癌后立即进行培美曲塞加最佳支持治疗与最佳支持治疗的III期，双盲，安慰剂对照研究的治疗原理和研究设计
3. PARAMOUNT: Final Overall Survival (OS) Results of the Phase III Study of Maintenance Pemetrexed (pem) Plus Best Supportive Care (BSC) Versus Placebo (plb) Plus BSC Immediately Following Induction Treatment With Pem Plus Cisplatin (Cis) for Advanced Nonsquamous (NS) Non-Small Cell Lung Cancer (NSCLC) [J] . Clinical advances in hematology & oncology: H&O . 2012,第Suppla11期

机译：PARAMOUNT：培美曲塞（pem）+最佳支持治疗（BSC）与安慰剂（plb）+ BSC维持治疗的培美曲塞（pem）加BSC对晚期非鳞状（NS）诱导后立即进行的III期研究的最终总体生存（OS）结果非小细胞肺癌（NSCLC）
4. Treatment rationale and study design for a phase III double-blind placebo-controlled study of maintenance pemetrexed plus best supportive care versus best supportive care immediately following induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small cell lung cancer [O] . Luis G Paz-Ares, Sedat Altug, Alexandra Thareau Vaury, 2010

机译：培美曲塞加顺铂治疗晚期非鳞状非小细胞肺癌后立即进行培美曲塞加最佳支持治疗与最佳支持治疗的III期双盲安慰剂对照研究的治疗原理和研究设计
5. Long-Term and Low-Grade Safety Results of a Phase III Study (PARAMOUNT): Maintenance Pemetrexed Plus Best Supportive Care Versus Placebo Plus Best Supportive Care Immediately After Induction Treatment With Pemetrexed Plus Cisplatin for Advanced Nonsquamous Non–Small-Cell Lung Cancer [O] . Pujol Jean-Louis, Paz-Ares Luis, de Marinis Filippo, 2014

机译：三期研究（PARAMOUNT）的长期和低度安全性结果：培美曲塞加最佳支持治疗与安慰剂加最佳支持治疗的比较，培美曲塞加顺铂治疗晚期非鳞状非小细胞肺癌后应立即进行。

Evaluation of changes in renal function in PARAMOUNT: a phase III study of maintenance pemetrexed plus best supportive care versus placebo plus best supportive care after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer

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