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Nano-Scale Gene Delivery Systems: Current Technology, Obstacles, and Future Directions

机译：纳米级基因递送系统：目前的技术，障碍和未来方向

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Within the different applications of nanomedicine currently being developed, nano-gene delivery is appearing as an exciting new technique with the possibility to overcome recognised hurdles and several biological and medical needs. The central component of all delivery systems is the requirement for the delivery of genetic material into cells, and for them to eventually reside in the nucleus where their desired function will be exposed. However, genetic material does not passively enter cells; thus, a delivery system is necessary. The emerging field of nano-gene delivery exploits the use of new materials and the properties that arise at the nanometre-scale to produce delivery vectors that can effectively deliver genetic material into a variety of different types of cells. The novel physicochemical properties of the new delivery vectors can be used to address the current challenges existing in nucleic acid delivery in vitro and in vivo. While there is a growing interest in nanostructure-based gene delivery, the field is still in its infancy, and there is yet much to discover about nanostructures and their physicochemical properties in a biological context.
机译：在目前正在开发的纳米医生的不同应用中，纳米基因递送出现为令人兴奋的新技术，可以克服公认的障碍和几种生物和医疗需求。所有递送系统的中心部件是要求将遗传物质传递到细胞中，并且它们最终将其存在于其所需功能的核中。然而，遗传物质不会被动地进入细胞;因此，需要递送系统。纳米基因递送的新出现领域利用新材料和在纳米级上产生的性质产生的性质，以产生可以有效地将遗传物质赋予各种不同类型的细胞的递送载体。新型递送载体的新型物理化学性质可用于解决体外和体内核酸输送中存在的当前挑战。虽然对基于纳米结构的基因递送的兴趣日益增长，但该领域仍处于初期，并且在生物学环境中仍然存在关于纳米结构及其物理化学性质的缺点。

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