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Editorial: Nuclear image-guided personalized treatment and prevention of cancers

机译：编辑：核图像导向个性化治疗和预防癌症

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摘要

Among molecular imaging modalities, nuclear imaging agent is the most sensitive and could provide target specific information. Positron emission tomography (PET) and single photon emission computed tomography (SPECT) nuclear molecular imaging agents generate information on target expression as well as function, pathway activity and cell migration in the intact organism. Molecular imaging agents by PET and SPECT are able to support proof-of-concept in translational drug discovery, development, delivery, pharmacokinetics/pharmacodynamics, pre-clinical validation and clinical staging, grading and differential diagnosis in cancers. Cellular imaging by PET and SPECT provides valuable information in monitoring and guiding clinical trial in the treatment of malignant and other diseases. PET and SPECT agents show high specific activities because they are made through a nuclear transformation and use carrier free forms of isotopes. On the other hand, CT, MRI, and ultrasonography are prognostic tools because they do not provide cellular target information, thus, assessment of the effectiveness of molecular targeted cancer therapy is not sufficient.
机译：在分子成像模式中，核成像剂是最敏感的并且可以提供目标特定信息。正电子发射断层扫描（PET）和单光子发射计算断层扫描（SPECT）核分子成像试剂产生有关靶表达的信息，以及在完整生物体中的功能，途径活性和细胞迁移。 PET和SPECT的分子成像剂能够支持转化药物发现，发育，递送，药代动力学/药效学，临床前验证和临床分期，分级和鉴别诊断的概念证明。 PET和SPECT的蜂窝成像提供了在监测和指导临床试验中治疗恶性和其他疾病的临床试验。宠物和SPECT代理表现出高的特定活动，因为它们是通过核转化进行的，并使用载体自由形式的同位素。另一方面，CT，MRI和超声检查是预后工具，因为它们不提供蜂窝目标信息，因此，评估分子靶向癌症治疗的有效性的方法是不够的。

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  • 来源
    《Current medicinal chemistry》 |2012年第20期|共2页
  • 作者

    YangD.J.; KongF.; ShenL.-H.; InoueT.; ZakkoS.;

  • 作者单位

    University of Texas MD Anderson Cancer Center Houston TX United States;

    University of Texas MD Anderson Cancer Center Houston TX United States;

    Institute of Nuclear Energy Research Atomic Energy Council Jiaan Village Longtan Township;

    Department of Radiology Yokohama City University Graduate School of Medicine Yokohama Japan;

    Hospital Amd Health Care Professional (Present) Falkirk United Kingdom;

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  • 正文语种 eng
  • 中图分类 药学;
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