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Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats

机译：Wistar大鼠邻苯二甲酸盐和双酚A-亚级口腔毒性研究的混合物的毒性作用

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Phthalates and bisphenol A, classified as endocrine disruptors, have weak estrogenic, anti-androgenic properties, and affect thyroid hormone regulation. The aim of this study on male rats was to compare the subacute toxic effects of low doses of single compounds (bis (2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), and bisphenol A (BPA)) with the effects of their mixture through different biochemical, hormonal, and hematological parameters. Rats were divided into five experimental groups: Control (corn oil), DEHP (50 mg/kg b.w./day), DBP (50 mg/kg b.w./day), BPA (25 mg/kg b.w./day), and MIX (50 mg/kg b.w./day DEHP + 50 mg/kg b.w/day DBP + 25 mg/kg b.w./day BPA). Animals were sacrificed after 28 days of oral treatment and blood was collected for further analysis. The results demonstrated that the mixture produced significant changes in lipid profile, liver-related biochemical parameters, and glucose level. Furthermore, the opposite effects of single substances on the thyroxine level have been shown in comparison with the mixture, as well as a more pronounced effect of the mixture on testosterone level. This study contributes to the body of knowledge on the toxicology of mixtures and gives one more evidence of the paramount importance of mixture toxicity studies, especially in assessing the endocrine disruptive effects of chemicals.
机译：邻苯二甲酸盐和双酚A分类为内分泌破坏剂，具有薄弱的雌激素，抗雄激素性能，并影响甲状腺激素调节。该研究对雄性大鼠的目的是将低剂量的单个化合物（双（2-乙基己基）邻苯二甲酸酯（DEHP），邻苯二甲酸二丁酯（DBP）和双酚A（BPA）的副病毒毒性作用进行比较它们通过不同的生物化学，激素和血液学参数的混合物。将大鼠分为五个实验组：对照（玉米油），DEHP（50mg / kg BW /天），DBP（50mg / kg BW /天），BPA（25mg / kg BW /天），并混合（ 50 mg / kg Bw / day dehp + 50 mg / kg bw / day dbp + 25 mg / kg bw / day bpa）。在28天的口服处理后处死动物，收集血液以进一步分析。结果表明，该混合物在脂质型材，肝相关的生化参数和葡萄糖水平中产生了显着的变化。此外，已与混合物相比显示单个物质对甲状腺素水平对甲状腺素水平的相反影响，以及对睾酮水平的混合物的更明显的效果。本研究有助于了对混合物毒理学的知识，并提供了一种更重要的毒性研究至关重要的证据，特别是在评估化学品的内分泌破坏性影响方面。

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