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Alzheimer's Disease and Exercise: A Literature Review

机译:阿尔茨海默病和锻炼:文献综述

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摘要

Alzheimer's disease (AD) is a progressive neurodegenerative disease that impairs memory and cognitive judgment. It is the leading cause of dementia in late adult life and is associated with a significant social burden and increased morbidity and mortality in the elderly. Because of mixed effectiveness of medications, exercise has been considered as a treatment for pre-clinical AD, late stage AD, and as a prevention strategy. Exercise appears to improve brain blood flow, increase hippocampal volume, and improve neurogenesis. Prospective studies indicate that physical inactivity is one of the most common preventable risk factors for developing AD and that higher physical activity levels are associated with a reduced risk of development of disease. Exercise as a treatment for AD shows improvement in cognitive function, decreased neuropsychiatric symptoms, and a slower decline in activities of daily living (ADL). Exercise has been shown to have fewer side effects and better adherence compared to medications.
机译:阿尔茨海默病(AD)是一种累进的神经变性疾病,可损害记忆和认知判断。它是晚年生命中痴呆症的主要原因,与老年人的发病率和死亡率增加,有关。由于药物的混合效果,运动被认为是临床前广告,晚期广告的治疗和作为预防策略的治疗方法。运动似乎改善脑血流量,增加海马体积,改善神经发生。前瞻性研究表明,物理不活动是开发广告的最常见的可预防危险因素之一,并且较高的身体活动水平与降低的疾病风险降低。作为AD治疗的锻炼显示认知功能的改善,降低神经精神症状,以及日常生活活动的速度较慢下降(ADL)。与药物相比,运动已经显示出副作用较少,更好的依从性。

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