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Mesenchymal Stem Cells, Immune Cells and Tumor Cells Crosstalk: A Sinister Triangle in the Tumor Microenvironment

机译:间充质干细胞,免疫细胞和肿瘤细胞串扰:在肿瘤微环境中的静脉三角形

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摘要

Mesenchymal Stem Cells [MSCs] are a heterogeneous population of fibroblast-like cells which maintain self-renewability and pluripotency. Many studies have demonstrated the immunomodulatory effects of MSCs on the innate and adaptive immune cells. As a result of interactions with tumor cells, microenvironment and immune-stimulating milieu, MSCs contribute to tumor progression by several mechanisms, including sustained proliferative signal in Cancer Stem Cells [CSCs], inhibition of tumor cell apoptosis, transition to Tumor-Associated Fibroblasts [TAFs], promotion of angiogenesis, stimulation of Epithelial-Mesenchymal Transition [EMT], suppression of immune responses, and consequential promotion of tumor metastasis. Here, we present an overview of the latest findings on Janus-faced roles that MSCs play in the Tumor Microenvironment [TME], with a concise focus on innate and adaptive immune responses.
机译:间充质干细胞[MSCs]是相成纤维细胞样细胞的异质群,其维持自我再生性和多能性。 许多研究已经证明了MSCs对先天和适应性免疫细胞的免疫调节作用。 由于与肿瘤细胞的相互作用,微环境和免疫刺激的Milieu,MSCs通过几种机制有助于肿瘤进展,包括癌症干细胞[CSCs]中的持续增殖信号,抑制肿瘤细胞凋亡,过渡到肿瘤相关成纤维细胞[ TAFS],促进血管生成,刺激上皮 - 间充质转换[EMT],抑制免疫应答,以及肿瘤转移的相应促进。 在这里,我们概述了MSCS在肿瘤微环境[TME]中的janus面对角色的最新发现的概述,简明扼要的是先天和适应性免疫应答。

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