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Breath testing for the diagnosis of pancreatic disease

机译：呼吸测试对胰腺疾病的诊断

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Purpose of review Pancreatic function tests are mainly used for the diagnosis of exocrine pancreatic insufficiency (EPI) in patients with pancreatic diseases or after pancreatic or gastric surgery. Breath tests evaluate not just pancreatic secretion but the digestion capacity of the pancreas. These tests are good candidates for the diagnosis of EPI as they are noninvasive, accurate and easy to apply to clinical practice. Recent findings The(13)C-labelled mixed triglyceride (MTG) breath test has been optimized and validated against adequate reference methods for the diagnosis of EPI in patients with chronic pancreatitis and for the evaluation of the efficacy of pancreatic enzyme replacement therapy (PERT). In addition, reported(13)C-MTG breath test results in patients with other pancreatic diseases and after pancreatic and gastric surgery support the accuracy and clinical applicability of this test. The evidence of pancreatic function breath tests with other(13)C-labelled substrates is limited. Increasing evidence supports the accuracy and clinical usefulness of the(13)C-MTG breath test for the diagnosis of EPI and the evaluation of the efficacy of PERT in different clinical conditions. Commercial availability of this test is required for a wide clinical use. The use of optimized and validated breath test protocols is mandatory.
机译：审查胰腺功能试验的目的主要用于胰腺疾病或胃手术后患者外分胰腺功能不全（EPI）的诊断。呼气测试不仅仅评估胰腺分泌，而是胰腺的消化能力。这些测试是诊断EPI的良好候选者，因为它们是非侵入性的，准确且易于适用于临床实践。最近的发现（13）C-标记的混合甘油三酯（MTG）呼气试验已经过优化和验证了慢性胰腺炎患者诊断EPI的适当参考方法和评估胰酶酶替代治疗（PERT）的疗效进行评估。此外，报告（13）C-MTG呼吸试验结果其他胰腺疾病患者和胰腺手术后支持该试验的准确性和临床适用性。用其他（13）个C标记的底物有限胰腺功能呼气测试的证据是有限的。越来越多的证据支持（13）C-MTG呼气测试的准确性和临床有用性，以诊断EPI和Pert在不同临床条件下的疗效评估。广泛的临床使用需要进行此测试的商业可用性。使用优化和验证的呼气测试协议是强制性的。

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