...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current opinion in gastroenterology >Proton pump inhibitor-responsive esophageal eosinophilia: still a valid diagnosis?
【24h】

Proton pump inhibitor-responsive esophageal eosinophilia: still a valid diagnosis?

机译：质子泵抑制剂响应食管嗜酸性粒细胞：仍然是有效的诊断吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of reviewTo update rapidly evolving concepts regarding the controversial entity of 'proton pump inhibitor (PPI)-responsive esophageal eosinophilia,' referring to patients with clinical, endoscopic and histologic features of eosinophilic esophagitis (EoE) who achieve remission on PPI therapy.Recent findingsUp to half of pediatric and adult patients with typical EoE symptoms and histology achieve clinico-pathologic remission on PPI therapy, irrespective of whether esophageal pH monitoring demonstrates abnormal acid reflux. In patients with clinical and histologic features of EoE, genotypic and phenotypic features of PPI responders and nonresponders are virtually indistinguishable, and different from those of patients with gastroesophageal reflux disease. In PPI responders, PPIs effects on esophageal Th2 inflammation and gene expression are similar to those of topical steroids in PPI nonresponders. These therapies, along with diets, recently have been shown to be potentially interchangeable in two small series.SummaryProton pump inhibitor-responsive esophageal eosinophilia is an inappropriate disease descriptor, arbitrarily based on a response to a single drug, and should be abandoned. Patients who have esophageal eosinophilia and esophageal symptoms that resolve with PPI therapy have phenotypic, molecular, mechanistic, and therapeutic features indistinguishable from similar patients who do not respond to PPIs. These patients with PPI responsiveness should be considered within the spectrum of EoE.
机译：审查的目的更新有关“质子泵抑制剂（PPI） - 响应食管嗜酸性嗜酚虫病”的争议实体的快速发展概念，该概念是指患有在PPI治疗中缓解缓解的嗜酸性食道炎（EOE）的临床，内窥镜和组织学特征的患者的竞争实体。对于PPI治疗的典型EOE症状和组织学症状和组织学患者的一半儿科和成年患者，无论食管pH监测是否表现出异常的酸回流，无论是否对酸回流都存在临床疗法。在患有EOE的临床和组织学特征的患者中，PPI响应者和非反应者的基因型和表型特征几乎无法区分，与胃食管反流患者的患者不同。在PPI响应者中，对食管TH2炎症和基因表达的PPI效应与PPI无反应者的局部类固醇类似。这些疗法以及饮食最近被证明可能在两个小系列中潜在可互换。ummaryProton泵抑制剂响应性食管嗜酸性粒细胞是不恰当的疾病描述符，任意基于对单一药物的反应，并且应该被遗弃。具有食管嗜酸性粒细胞和食管症状的患者用PPI疗法分辨具有表型，分子，机械和治疗特征，与不响应PPI的类似患者难以区分。这些具有PPI响应性的患者应在EOE的光谱内考虑。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号