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首页> 外文期刊>Current opinion in gastroenterology >Advances in the diagnosis of cystic neoplasms of the pancreas
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Advances in the diagnosis of cystic neoplasms of the pancreas

机译：胰腺囊性肿瘤诊断的进展

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PURPOSE OF REVIEW: Management of pancreatic cystic neoplasms is challenging due to limitations of current diagnostic tests. There is considerable interest in developing an accurate and cost-effective diagnostic test (or panel of tests) to differentiate cyst types and to identify those which would benefit most from surgical resection. RECENT FINDINGS: Current multidetector computed tomography scans may have improved accuracy to distinguish between mucinous and nonmucinous cysts. Attempts to generate quantitative criteria from cross-sectional imaging to differentiate cyst types have yielded mixed results. DNA mutations and microRNA show promise in the ability to distinguish between mucinous and nonmucinous cysts. Cyst fluid mucin glycoproteins and cytokines may identify those cysts with high malignant potential. Proteomic analysis may yield other biomarker candidates. SUMMARY: Analysis of DNA mutations and proteins within pancreatic cyst fluid have identified potential biomarkers to aid with the management of patients with pancreatic cystic neoplasms.
机译：审查目的：由于当前诊断测试的局限性，胰腺囊性肿瘤的管理是挑战。对于开发准确且经济高效的诊断测试（或测试小组）来区分囊肿类型并鉴定这些从手术切除术中受益的诊断测试（或考验的面板）。最近的发现：目前的多选电视层析扫描扫描可能具有改善的准确性，以区分粘液和非含囊肿。试图从横截面成像产生定量标准以区分囊肿类型的混合结果。 DNA突变和MicroRNA在区分粘液和非含囊肿的能力中显示出许可。囊肿流体粘蛋白糖蛋白和细胞因子可以鉴定具有高恶性潜力的那些囊肿。蛋白质组学分析可以产生其他生物标志物候选者。发明内容：胰腺囊肿流体中的DNA突变和蛋白质的分析已经确定了潜在的生物标志物，以帮助管理胰腺囊性肿瘤患者。

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