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首页> 外文期刊>Current opinion in hematology >Age of blood: Does older blood yield poorer outcomes?
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Age of blood: Does older blood yield poorer outcomes?

机译：血年龄：较老的血液产生较差的结果吗？

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PURPOSE OF REVIEW: Possible adverse effects of prolonged storage of red blood cell concentrates (RBCs) are being formally assessed both by observational studies and in randomized controlled trials. New mechanisms have been put forth to explain earlier conflicting observations. This review summarizes ongoing investigations into clinical and basic science studies on RBC storage effects. RECENT FINDINGS: Research into possible deleterious clinical effects of prolonged storage of RBCs has explored the contribution of various RBC production aspects (e.g. overnight hold, centrifugation speed, storage solution), seldom previously reported. Other studies investigated putative underlying mechanisms like free iron, inflammation, cytokines, and so on. Many publications include multiple analyses, like different cut-off values for 'old', or taking into account both oldest and average RBC storage time. Also, more studies correct for possible confounding effects to get a better estimate of associations. An alarming and ironic observation is that several studies found higher risks with fresh RBCs after correction for confounding. The results from the first large randomized controlled trials show no differences between old and fresh RBCs. SUMMARY: We still do not know whether older red cells have adverse effects, and if so, what determines such clinical effects after transfusion of 'old' RBCs. RBC production factors, previously seldom reported, may play an important role and should be reported.
机译：审查目的：通过观察研究和随机对照试验在正式评估红细胞浓缩物（RBCS）的可能不良反应。已经提出了新的机制来解释早期的冲突观察。本综述总结了对RBC储存效果的临床和基础科学研究的持续调查。最近的结果：延长储存RBC的可能有害临床疗效已经探讨了各种RBC生产方面的贡献（例如，过夜持有，离心速度，储存解决方案），以前报道。其他研究调查了像游离铁，炎症，细胞因子等的推定的潜在机制。许多出版物包括多次分析，如“旧”的不同截止值，或者考虑到最古老和平均的RBC存储时间。此外，更多的研究对于可能的混淆效果来说是正确的，以获得更好的协会估计。令人震惊和讽刺的观察是，在纠正混淆后，几项研究发现了新鲜的RBC在新鲜的RBC中发现了更高的风险。第一个大型随机对照试验的结果表明，旧和新鲜RBC之间没有差异。摘要：我们仍然不知道老年红细胞是否具有不利影响，如果是这样，则确定在输血后的临床效果。 RBC生产因素，以前很少报告，可能发挥重要作用，并应报告。

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