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首页> 外文期刊>Current opinion in lipidology >The many faces of CD8 + T cells in atherosclerosis
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The many faces of CD8 + T cells in atherosclerosis

机译：动脉粥样硬化中CD8 + T细胞的许多面孔

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Purpose of review Atherosclerosis and the clinical consequence of cardiovascular disease remain the leading cause of death worldwide. Both an increase in cholesterol levels, as well as immune responses drive the pathogenesis of this disease. Although much is known about the role of many immune cell subsets in atherogenesis, research into the role of CD8~(+)T cells is limited. Recent findings Both atheroprotective and atherogenic functions of CD8~(+)T cells have been reported. On the one hand, the inflammatory cytokines produced by CD8~(+)T cells exacerbate inflammatory responses, and the cytotoxic activity of these cells toward lesion-stabilizing cells such as endothelial cells drives the progression and instability of atherosclerotic lesions. On the other hand, cytotoxic activity toward antigen presenting cells and the presence of regulatory CD8~(+)T-cell subsets dampen immunity and can limit atherosclerosis. Summary Here we review the different roles of CD8~(+)T cells in atherosclerosis and discuss possible treatment strategies targeting these cells to reduce atherosclerotic lesion burden.
机译：回顾动脉粥样硬化的目的和心血管疾病的临床后果保持全球死亡的首要原因。无论增加胆固醇水平，以及免疫应答带动本病的发病机制。虽然很多人知道许多免疫细胞亚群的动脉粥样硬化的作用，研究CD8〜+ T细胞的作用是有限的。最近的发现已经报道了CD8〜（+）T细胞的两个动脉粥样硬化和动脉粥样化的功能。在一方面，由CD8〜（+）T细胞产生的炎性细胞因子加剧炎症反应，并且这些细胞朝向病变稳定细胞如内皮细胞驱动的进展和粥样硬化病变的不稳定性的细胞毒性活性。在另一方面，朝向抗原呈递细胞的细胞毒活性和调节性CD8〜（+）的存在下T细胞亚群免疫浸湿并可以限制动脉粥样硬化。摘要这里，我们回顾CD8〜+ T细胞的不同作用在动脉粥样硬化，并讨论可能的治疗策略，针对这些细胞减少动脉粥样硬化病变的负担。

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