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首页> 外文期刊>Current opinion in lipidology >Apolipoprotein B100 autoimmunity and atherosclerosis-disease mechanisms and therapeutic potential
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Apolipoprotein B100 autoimmunity and atherosclerosis-disease mechanisms and therapeutic potential

机译：载脂蛋白B100自身免疫和动脉粥样硬化 - 疾病机制和治疗潜力

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PURPOSE OF REVIEW: Adaptive immune responses have been shown to play an important role in the atherosclerotic disease process and both pathogenic and protective immunity has been identified. Apolipoprotein (apo) B100 appears to be a key antigen and novel therapies modulating immune responses against apo B100 have shown promising results in experimental models. This review will discuss recent developments in the mechanistic understanding of apo B100 autoimmunity and approaches taken to use this knowledge for development of novel therapies. RECENT FINDINGS: It has recently been shown that not only apo B100 modified by oxidation but also nonmodified apo B100 is targeted by autoimmune responses. This implies that a corresponding set of regulatory T cells with the same antigen specificity must exist and that these cells under normal circumstances are able to prevent autoimmunity against LDL. Recent studies also suggest that the atheroprotective effect of apo B100 peptide immunization acts by re-enforcing the activity of such cells. SUMMARY: These novel findings suggest that aggravation of plaque inflammation may occur as a result of a local loss of tolerance against LDL in the plaque due to insufficient activity of regulatory T cells. Restoration of lost tolerance represents an interesting novel approach for treatment of cardiovascular disease.
机译：审查目的：已显示自适应免疫应答在动脉粥样硬化疾病过程中发挥重要作用，并鉴定了致病和保护性免疫。载脂蛋白（APO）B100似乎是抗原和调节APO B100的免疫反应的新疗法表明了实验模型的有希望的结果。本综述将讨论最近对APO B100自身免疫和方法的机械理解的发展，以利用这些知识开发新的疗法。最近的发现：最近表明不仅通过氧化修饰的APO B100，而且还由非副化化的APO B100通过自身免疫反应来靶向。这意味着必须存在相应的具有相同抗原特异性的调节性T细胞，并且在正常情况下，这些细胞能够防止对LDL的自身免疫。最近的研究还表明APO B100肽免疫的动脉保护作用通过重新加强这些细胞的活性而作用。发明内容：这些新发现表明，由于调节性T细胞的活性不足，由于对斑块的局部耐受性局部耐受性的局部耐受性，可能发生斑块炎症的加重。损失耐受性恢复代表了一种用于治疗心血管疾病的有趣新方法。

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