LDL and foam cell formation as the basis of atherogenesis

Orekhov Alexander N.

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LDL and foam cell formation as the basis of atherogenesis

机译：LDL和泡沫细胞形成为肌动α的基础

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Purpose of reviewLipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose of this review is to describe the recent data related to the possible mechanisms of LDL-induced formation of lipid-laden foam cells and their role in the onset and development of atherosclerotic lesion.Recent findingsThe most interesting current studies are related to the factors affecting foam cell formation.SummaryThe phenomenon of lipid accumulation in cultured cells became the basis for creating a cellular test system that has already been successfully applied for development of drugs possessing direct antiatherosclerotic activity, and then the efficacy of these drugs was demonstrated in clinical studies. Moreover, this test system could be used for diagnostic assessing lipoproteins atherogenicity.

机译：审查司林诱导的细胞内脂质积累（泡沫细胞形成）是下潜动脉细胞水平的血液发生的触发。本次审查的目的是描述与LDL诱导的LDL诱导的脂质泡沫细胞形成的可能机制相关的数据及其在动脉粥样硬化病变的发作和发育中的作用。最有趣的目前研究与因素有关影响泡沫细胞形成。umalary培养细胞中脂质积累现象成为创造一种细胞试验系统的基础，该细胞试验系统已经成功地应用于具有直接抗炎症活性的药物，然后在临床研究中证明了这些药物的疗效。此外，该测试系统可用于诊断评估脂蛋白致动脉粥样味性。

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来源
《Current opinion in lipidology》 |2018年第4期|共6页
作者
Orekhov Alexander N.;
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作者单位

Skolkovo Innovat Ctr Lab Angiopatol Inst Gen Pathol &

Pathophysiol Moscow Russia;

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原文格式 PDF
正文语种 eng
中图分类生物化学;
关键词
fluid-phase pinocytosis; intracellular lipids; multiply modified LDL;

机译：流体相吞细胞症;细胞内脂质;多次改性LDL;

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1. LDL and foam cell formation as the basis of atherogenesis [J] . Orekhov Alexander N. Current opinion in lipidology . 2018,第4期

机译：LDL和泡沫细胞形成为肌动α的基础
2. Inhibition of LDL oxidation and oxidized LDL-induced foam cell formation in RAW 264.7 cells show anti-atherogenic properties of a foliar methanol extract of Scoparia dulcis [J] . Sinjitha S. Nambiar, Nandini Prasad Shetty, Praveena Bhatt, Pharmacognosy magazine . 2014,第Suppla2期

机译：在RAW 264.7细胞中抑制LDL氧化和氧化LDL诱导的泡沫细胞形成显示出苏S的叶甲醇提取物的抗动脉粥样硬化特性
3. Vitamin E supplementation of human macrophages prevents neither foam cell formation nor increased susceptibility of foam cells to lysis by oxidized LDL. [J] . Asmis R, Jelk J Arteriosclerosis, thrombosis, and vascular biology . 2000,第9期

机译：补充人类巨噬细胞的维生素E既不会防止泡沫细胞形成，也不会防止泡沫细胞被氧化的LDL裂解的敏感性增加。
4. Macrophage Foam Cell Formation Mediated by Receptor-Independent Macropinocytosis of LDL [C] . H.S. Kruth, C. Buono, S.W. Waldo, International Congress on Coronary Artery Disease . 2007

机译：由受体无关的LDL介导的巨噬细胞泡沫细胞形成
5. Molecular mechanisms involved in adenosine receptor mediated suppression of foam cell formation: A2A adenosine receptor activation decreases foam cell formation by enhancing ABCA1 and 27-hydroxylase dependent cholesterol efflux. [D] . Bingham, Taiese Crystal. 2009

机译：参与腺苷受体介导的泡沫细胞形成抑制的分子机制：A2A腺苷受体激活通过增强ABCA1和27-羟化酶依赖性胆固醇外排而减少泡沫细胞形成。
6. K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells [O] . Paula Costales, Pablo Fuentes-Prior, Jose Castellano, 2015

机译：低密度脂蛋白（LDL）受体相关蛋白1（LRP1）的K结构域CR9对于从人血管平滑肌细胞聚集LDL诱导的泡沫细胞形成至关重要
7. Vitamin E Supplementation of Human Macrophages Prevents Neither Foam Cell Formation Nor Increased Susceptibility of Foam Cells to Lysis by Oxidized LDL [O] . Reto Asmis, Jennifer Jelk 2000

机译：人类巨噬细胞的维生素E补充剂既没有泡沫细胞形成也不是通过氧化LDL溶解泡沫细胞的易感性

LDL and foam cell formation as the basis of atherogenesis

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