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Serum tumor markers and testicular germ cell tumors: a primer for radiologists

机译:血清肿瘤标志物和睾丸生殖细胞瘤:放射科医生的底漆

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摘要

Serum tumor markers (STMs) play a critical role in the diagnosis, staging and follow-up of both seminomatous and nonseminomatous testicular germ cell neoplasms. Levels of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH), especially those measured after orchiectomy, also have implications for patient prognosis. Given that testicular germ cell tumors represent the most common solid tumor in men aged 20-34, radiologists must have familiarity with the clinical utilization and implications of these STMs. This article will review the classical patterns of STM elevation most commonly seen in pure seminomatous and nonseminomatous germ cell tumors while also providing case-based examples highlighting the importance of STM correlation with imaging. The role of STMs in clinical staging and disease surveillance will also be discussed.
机译:血清肿瘤标志物(STMS)在诊断,分期和后续睾丸和非致睾丸生殖细胞瘤的诊断,分期和随访中起重要作用。 α-胎蛋白(AFP),人绒毛膜促性腺激素(HCG)和乳酸脱氢酶(LDH)的水平,尤其是睾丸切除术后测量的乳酸脱氢酶(LDH),对患者预后的影响也有影响。 鉴于睾丸生殖细胞肿瘤代表20-34岁的男性中最常见的实体肿瘤,放射科医师必须熟悉这些STM的临床利用和含义。 本文将审查纯粹的研讨会和非致肢体胚芽细胞肿瘤中最常见的STM升高的经典模式,同时还提供基于案例的例子,突出了与成像的STM相关性的重要性。 还讨论了STMS在临床分期和疾病监测中的作用。

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