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首页> 外文期刊>Abdominal radiology. >Correlation between SACE (Subjective Angiographic Chemoembolization Endpoint) score and tumor response and its impact on survival after DEB-TACE in patients with hepatocellular carcinoma
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Correlation between SACE (Subjective Angiographic Chemoembolization Endpoint) score and tumor response and its impact on survival after DEB-TACE in patients with hepatocellular carcinoma

机译：SACE（主观血管造影化疗栓塞终点）评分和肿瘤反应的相关性及其对肝细胞癌患者蛋白质蛋白质的生存影响

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Purpose To asses angiographic and computed tomographic success criteria during and after transcatheter arterial drug-elut-ing bead chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC) and its impact on progression-free survival (PFS) and overall survival (OS). Methods In this retrospective single-center study, 50 patients with unresectable HCC having undergone DEB-TACE from January 2010 to July 2015 were assessed. The angiographic endpoint was classified by Subjective Angiographic Chemoembolization Endpoint (SACE) scale. Relative tumor density in arterial (D_Art) and portal venous phase (D_PV) computed tomography post- versus pre-DEB-TACE were calculated, respectively. Tumor response according to modified Response Criteria in Solid Tumors (mRECIST) was assessed. Univariate Kaplan-Meier and Cox regression analysis were carried out. Results SACE scores I, II, III, and IV were found in 1 (2%), 20 (40%), 15 (30%), and 14 (28%) patients, respectively. Median OS and PFS were 14.2 and 5.5 months, respectively. Death rates at 6 months, 1 year and 2 years were 24%, 38%, and 52%, respectively. SACE score during DEB-TACE significantly correlated with local and overall mRECIST results (local:p<0.001, r=0.49, overall:p = 0.042, r=0.29) and inversely correlated with D_PV (p = 0.005, r = - 0.40). In univariate analysis, progressive disease (PD) according to mRECIST and increase of D_Alt and D_pv were associated with significantly shorter PFS. Modified RECIST independently predicted OS (hazard ratio for complete remission vs. PD = 0.15, 95% confidence interval 0.03-0.68,p = 0.014). Conclusions A direct impact of SACE on PFS or OS could not be shown. However, SACE significantly correlated with local and overall mRECIST tumor response that again significantly predicted OS. We therefore postulate an indirect impact of SACE on OS. Consequently, complete embolization should be attempted.
机译：目的在肝细胞癌（HCC）患者的经截觉管动脉药物 - 洗脱珠化珠化珠化珠化（Deb-TACE）期间和经过经过者动脉药物 - 洗脱珠化珠化珠化（Deb-TACE）及其对无进展生存（PFS）和总体存活（OS ）。该回顾性单中心研究中的方法，评估了50例未调查的HCC患者，从2010年1月到2015年7月达到2015年7月。血管造影终点由主观血管造影化疗栓塞终点（SACE）规模分类。动脉（D_ART）和门静脉期（D_PV）计算断层扫描后的相对肿瘤密度分别计算出与预介乎预介性的。评估根据固体肿瘤的修饰响应标准（MRECART）的肿瘤反应。进行单变量Kaplan-Meier和Cox回归分析。结果SACE评分I，II，III和IV分别在1（2％），20％（40％），15（30％）和14名（28％）患者中发现。中位OS和PFS分别为14.2和5.5个月。 6个月，1年和2年的死亡率分别为24％，38％和52％。在DEB-TACE期间的SACE得分与本地和整体MRECIST结果显着相关（本地：P <0.001，R = 0.49，总体：P = 0.042，r = 0.29）并与D_PV成反比（P = 0.005，R = - 0.40） 。在单变量分析中，根据MRecist和D_Alt和D_PV的增加，渐进性疾病（PD）与PFS显着更短。改性重新入住独立预测的OS（完全缓解的危险比对PD = 0.15,95％置信区间0.03-0.68，P = 0.014）。结论无法显示SACE对PFS或OS上的直接影响。然而，SACE与局部和总体MRECART肿瘤反应显着相关，其再次显着预测OS。因此，我们假设SACE对OS的间接影响。因此，应尝试完全栓塞。

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