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Biliary and pancreatic complications of molecular targeted therapies in cancer imaging

机译：癌症成像中分子靶向疗法的胆道和胰腺并发症

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The purpose of this review is to familiarize radiologists with the different imaging manifestations of biliary and pancreatic toxicity of molecular targeted therapies. The advent of molecular targeted therapies for cancer treatment has prompted radiologists to be familiar with these new molecules, their patterns of response, and their class-specific toxicities. While liver and bowel toxicities have been extensively reported in literature, less is known about the pathogenesis and imaging of toxicity involving the pancreatobiliary system. Biliary and pancreatic toxicity of molecular targeted therapies present with variable manifestations and varying degrees of severity, from asymptomatic liver function tests elevation to acute pancreatitis or cholecystitis. Management of these conditions depends on the clinical scenario and the severity of the findings. In this article, we will (1) present the various classes of molecular targeted therapies most commonly associated with biliary and pancreatic toxicity; (2) illustrate imaging findings of drug-associated biliary and pancreatic injuries and their possible differential diagnosis; and (3) provide a guide for management of these conditions.
机译：本综述的目的是熟悉具有分子靶向疗法的胆道和胰腺毒性的不同成像表现的放射科医师。用于癌症治疗的分子靶向疗法的出现促使放射科医师熟悉这些新分子，它们的反应模式及其类特异性毒性。虽然在文献中已经广泛报道了肝脏和肠道毒性，但较少关于涉及胰腺系统的毒性的发病机制和成像。分子靶向治疗的胆道和胰腺毒性存在于可变表现和不同程度的严重程度，从无症状肝功能试验到急性胰腺炎或胆囊炎。这些条件的管理取决于临床情景和调查结果的严重程度。在本文中，我们将（1）介绍与胆道和胰腺毒性最常见的各类分子靶向治疗; （2）说明药物相关胆道和胰腺损伤的成像结果及其可能的鉴别诊断; （3）提供管理这些条件的指南。

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