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首页> 外文期刊>Abdominal radiology. >Intravoxel incoherent motion diffusion-weighted MR imaging of solid pancreatic masses: reliability and usefulness for characterization
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Intravoxel incoherent motion diffusion-weighted MR imaging of solid pancreatic masses: reliability and usefulness for characterization

机译：椎间杂环相密运动扩散加权固体胰腺质量的MR成像：表征的可靠性和有用性

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Purpose: IVIM-DW imaging has shown potential usefulness in the study of pancreatic lesions. Controversial results are available regarding the reliability of the measurements of IVIM-derived parameters. The aim of this study was to evaluate the reliability and the diagnostic potential of IVIM-derived parameters in differentiation among focal solid pancreatic lesions and normal pancreas (NP). Methods: Fifty-seven patients (34 carcinomas-PDACs, 18 neuroendocrine neoplasms-panNENs, and 5 autoimmune pancreatitis-AIP) and 50 subjects with NP underwent 1.5-T MR imaging including IVIM-DWI. Images were analyzed by two independent readers. Apparent diffusion coefficient (ADC), slow component of diffusion (D), incoherent microcirculation (Dp), and perfusion fraction (f) were calculated. Interobserver reliability was assessed with intraclass correlation coefficient (ICC). A Kruskal-Wallis H test with Steel-Dwass post hoc test was used for comparison. The diagnostic performance of each parameter was evaluated through receiver operating characteristic (ROC) curve analysis. Results: Overall interobserver agreement was excellent (ICC = 0.860, 0.937, 0.968, and 0.983 for ADC, D, Dp, and f). D, Dp, and f significantly differed among PDACs and panNENs (p = 0.002, < 0.001, and < 0.001), albeit without significant difference at the pairwise comparison of ROC curves (p = 0.08-0.74). Perfusion fraction was higher in AIP compared with PDACs (p = 0.024; AUC = 0.735). Dp and f were higher in panNENs compared with AIP (p = 0.029 and 0.023), without differences at ROC analysis (p = 0.07). Conclusions: IVIM-derived parameters have excellent reliability and could help in differentiation among solid pancreatic lesions and NP.
机译：目的：IVIM-DW成像在胰腺病变研究中表明了潜在的有用性。有争议的结果是关于IVIM衍生参数测量的可靠性的可用性。本研究的目的是评估局灶性胰腺病变和正常胰腺（NP）之间分化中IVIM衍生参数的可靠性和诊断潜力。方法：五十七名患者（34名癌症-PDACS，18名神经内分泌肿瘤 - PANNENS和5个自身免疫胰腺炎AIP）和50名受试者的NP接受1.5-T先生成像，包括IVIM-DWI。两个独立读者分析了图像。表观扩散系数（ADC），扩散（D）的缓慢分量，计算出来，不相停的微循环（DP）和灌注级分（F）。使用脑内相关系数（ICC）评估了Interobserver可靠性。使用钢铁DWASS后HOC测试的Kruskal-Wallis H测试进行比较。通过接收器操作特性（ROC）曲线分析评估每个参数的诊断性能。结果：ADC，D，DP和F的总体interobserver协议非常好（ICC = 0.860,0.937,0.968和0.983）。 D，DP和F显着不同，PDAC和Pan长（P = 0.002，<0.001和<0.001），尽管在ROC曲线的成对比较下没有显着差异（P = 0.08-0.74）。与PDAcs相比，AIP灌注级分较高（P = 0.024; AUC = 0.735）。 Pannens的DP和F与AIP（P = 0.029和0.023）相比较高，无需ROC分析差异（P = 0.07）。结论：IVIM衍生的参数具有优异的可靠性，并且可以帮助固体胰腺病变和NP之间的分化。

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