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Assessing renal parenchymal volume on unenhanced ct as a marker for predicting renal function in patients with chronic kidney disease

机译：在慢性肾疾病患者中评估未加入CT作为预测肾功能的肾实质体积

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摘要

Objectives: To estimate renal volume in chronic kidney disease (CKD) patients using a semiautomated software and compare them with split renal function estimates from radionuclide renogram (RR). We proposed that renal volume from unenhanced computed tomography (CT) scans may serve as surrogate marker for assessing renal function in CKD patients. Materials and Methods: Unenhanced multidetector CT scans of 26 patients with CKD (estimated glomerular filtration rate [eGFR] <60 mL/kg/body surface area [BSA]) and 10 controls (eGFR >60 mL/kg/BSA) were analyzed to calculate renal volumes using a semiautomated software (AMIRAV5.2.0). Volumes obtained were then correlated with corresponding eGFR and split renal function estimates from RR. Volumes were also compared with those obtained on enhanced scans in 10 cases (five disease group, five controls). Bland-Altman analysis was used to assess agreement between methods. Results: A moderately positive correlation was found between renal volume obtained on unenhanced CT and eGFR (r = 0.65, P < .0001), whereas a significantly high correlation with split function estimates from RR (r = 0.95, P < .001) was found. Bland-Altman analysis revealed a good agreement between renal volume from CT and renal function from RR (34/36 observations were within 95% CI and there were two outliers). Correlation between volumes obtained from unenhanced and enhanced CT scans was also significant (r = 0.96). Conclusion: In patients with CKD, renal volume derived from unenhanced CT can possibly serve as a surrogate marker for assessing and monitoring renal function reserves to plan further management.
机译：目的：估算慢性肾病（CKD）患者的肾脏体积使用半动物软件，并将它们与来自放射性核素录音图（RR）的分裂肾功能估算进行比较。我们提出，来自未加入计算断层扫描（CT）扫描的肾脏体积可用作评估CKD患者肾功能的替代标志物。材料和方法：26例CKD患者的未加薪多票CT扫描（估计肾小球过滤速率[EGFR] <60mL / kg /体表面积[BSA]）和10个对照（EGFR> 60ml / kg / bsa）使用半动物质软件（Amirav5.2.0）计算肾脏体积。然后，获得的体积与相应的EGFR和来自RR的分裂肾功能估计相关。还与10例（五种疾病组，五种对照）增强扫描获得的人进行比较。 Bland-Altman分析用于评估方法之间的协议。结果：在未加强CT和EGFR（R = 0.65，P <.0001）上获得的肾脏体积之间的适度正相关，而来自RR的分裂功能估计显着高的相关性（r = 0.95，p <.001）是成立。 Bland-Altman分析显示，来自RR的CT和肾功能之间的肾脏体积之间的良好一致（34/36观察在95％CI内，有两个异常值）。从未加强和增强的CT扫描获得的体积之间的相关性也显着（r = 0.96）。结论：在CKD患者中，衍生自未加薪CT的肾体积可能是用于评估和监测肾功能储备的替代标记，以计划进一步管理。

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  • 来源
    《Academic radiology》 |2012年第6期|共7页
  • 作者

    GuptaS.; SinghA.H.; ShabbirA.; HahnP.F.; HarrisG.; SahaniD.;

  • 作者单位

    Department of Abdominal and Interventional Radiology Massachusetts General Hospital 55 Fruit;

    Department of 3-D Imaging Massachusetts General Hospital 25 New Cgardon Street Suite 400 Boston;

    Aga Khan University Karachi Pakistan;

    Department of Abdominal and Interventional Radiology Massachusetts General Hospital 55 Fruit;

    Department of 3-D Imaging Massachusetts General Hospital 25 New Cgardon Street Suite 400 Boston;

    Department of Abdominal and Interventional Radiology Massachusetts General Hospital 55 Fruit;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Chronic kidney disease; Renal volumetry; Split renal function;

    机译：慢性肾病;肾脏体积;分裂肾功能;

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