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首页> 外文期刊>Academic radiology >Node/Aorta and Node/Liver SUV Ratios from 18F-FDG PET/CT May Improve the Detection of Occult Mediastinal Lymph Node Metastases in Patients with Non-Small Cell Lung Carcinoma
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Node/Aorta and Node/Liver SUV Ratios from 18F-FDG PET/CT May Improve the Detection of Occult Mediastinal Lymph Node Metastases in Patients with Non-Small Cell Lung Carcinoma

机译：18F-FDG PET / CT的节点/主动脉和节点/肝脏SUV比率可以改善非小细胞肺癌患者隐匿性纵隔淋巴结转移的检测

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摘要

Rationale and Objectives: Research suggests that the semiquantitative determination of nodal 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET)/computed tomography (CT) may be useful for the assessment of mediastinal metastases in patients with non-small-cell lung carcinoma (NSCLC). The aim of this study was to evaluate the diagnostic ability of using different standardized uptake value (SUV) parameters in the detection of ipsilateral mediastinal (N2) disease. Materials and Methods: A total of 102 patients newly diagnosed with non-small-cell lung carcinoma who underwent 18F-FDG PET/CT before surgery and had not received prior therapy were retrospectively included. All patients underwent surgical resection of the primary tumor and mediastinal lymph node dissection. On a station-based analysis, different SUV parameters (eg, mediastinal lymph node SUV, node/aorta SUV ratio, and node/liver SUV ratio) were evaluated using the histopathologic results as the reference standard. The optimal cutoff value for each SUV parameter was determined with receiver-operating characteristic curve analysis. Results: The areas under the receiver-operating characteristic curves were 0.674, 0.693, and 0.715 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively (P .05). With cutoff values of 3.15, 1.37, and 1.02 for node SUV, node/aorta SUV ratio, and node/liver SUV ratio, respectively, the sensitivity of 18F-FDG PET/CT for N2 staging was 57.1%, 85.7%, and 71.4%, and specificity was 74.2%, 50.5%, and 61.9%. Conclusions: Compared to node SUV alone, the use of node/aorta and node/liver SUV ratios resulted in improved detection of N2 metastases. The two SUV parameters may potentially improve the diagnostic accuracy of 18F-FDG PET/CT for the diagnosis of N2 disease in patients with non-small-cell lung carcinoma.
机译：理由和目的：研究表明，Nodal 18F-氟脱氧葡萄糖（FDG）对正电子发射断层扫描（PET）/计算机断层扫描（CT）的分解测定可用于评估非小细胞肺患者的纵隔转移癌（NSCLC）。本研究的目的是评估在检测中使用不同标准化摄取值（SUV）参数的诊断能力纵隔（N2）疾病。材料和方法：共有102例新诊断患有非小细胞肺癌，在手术前接受了18F-FDG PET / CT，并未收到先前治疗。所有患者均接受了原发性肿瘤和纵隔淋巴结解剖手术切除。在基于驻地的分析中，使用组织病理学结果作为参考标准，评估不同SUV参数（例如，纵隔淋巴结SUV，节点/主动脉SUV比和节点/肝脏SUV比率）。通过接收器操作特性曲线分析确定每个SUV参数的最佳截止值。结果：接收器操作特性曲线下的区域分别为0.674,0.693和0.715，分别为节点/主动脉SUV比和节点/肝脏SUV比（P <.05）。对于节点SUV，节点/主动脉SUV比和节点/肝脏SUV比的截止值分别为3.15,1.37和1.02，N2分期的18F-FDG PET / CT的灵敏度为57.1％，85.7％和71.4 ％，特异性为74.2％，50.5％和61.9％。结论：与单独的节点SUV相比，使用节点/主动脉和节点/肝脏SUV比率导致改善N2转移的检测。两个SUV参数可能会提高非小细胞肺癌患者诊断N2疾病的18F-FDG PET / CT的诊断准确性。

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  • 来源
    《Academic radiology》 |2012年第6期|共8页
  • 作者

    KuoW.-H.; WuY.-C.; WuC.-Y.; HoK.-C.; ChiuP.-H.; WangC.-W.; ChangC.-J.; YuC.-T.; YenT.-C.; LinC.;

  • 作者单位

    Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Chang;

    Division of Chest Surgical Oncology Department of Surgery Chang Gung Memorial Hospital Chang;

    Division of Chest Surgical Oncology Department of Surgery Chang Gung Memorial Hospital Chang;

    Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Chang;

    Biostatistical Center for Clinical Research Chang Gung Memorial Hospital Chang Gung University;

    Department of Pathology Chang Gung Memorial Hospital Chang Gung University College of Medicine;

    Biostatistical Center for Clinical Research Chang Gung Memorial Hospital Chang Gung University;

    Division of Chest Medicine Department of Internal Medicine Chang Gung Memorial Hospital Chang;

    Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Chang;

    Department of Nuclear Medicine and Molecular Imaging Center Chang Gung Memorial Hospital Chang;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Mediastinal lymph node; Node/aorta SUV ratio; Node/liver SUV ratio; Non-small-cell lung cancer; Positron emission tomography;

    机译：纵隔淋巴结;节点/主动脉SUV比率;节点/肝SUV比率;非小细胞肺癌;正电子发射断层扫描;

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