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首页> 外文期刊>Academic radiology >Semiquantitative Analysis of Maximum Standardized Uptake Values of Regional Lymph Nodes in Inflammatory Breast Cancer. Is There a Reliable Threshold for Differentiating Benign from Malignant?
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Semiquantitative Analysis of Maximum Standardized Uptake Values of Regional Lymph Nodes in Inflammatory Breast Cancer. Is There a Reliable Threshold for Differentiating Benign from Malignant?

机译：炎症乳腺癌区域淋巴结最大标准化摄取值的半定量分析。 有没有可靠的阈值来区分恶性肿瘤？

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摘要

Rationale and Objectives: The aim of this study was to determine an optimum standardized uptake value (SUV) threshold for identifying regional nodal metastasis on 18F-fluorodeoxyglucose (FDG) positron emission tomographic (PET)/computed tomographic (CT) studies of patients with inflammatory breast cancer. Materials and Methods: A database search was performed of patients newly diagnosed with inflammatory breast cancer who underwent 18F-FDG PET/CT imaging at the time of diagnosis at a single institution between January 1, 2001, and September 30, 2009. Three radiologists blinded to the histopathology of the regional lymph nodes retrospectively analyzed all 18F-FDG PET/CT images by measuring the maximum SUV (SUVmax) in visually abnormal nodes. The accuracy of 18F-FDG PET/CT image interpretation was correlated with histopathology when available. Receiver-operating characteristic curve analysis was performed to assess the diagnostic performance of PET/CT imaging. Sensitivity, specificity, positive predictive value, and negative predictive value were calculated using three different SUV cutoff values (2.0, 2.5, and 3.0). Results: A total of 888 regional nodal basins, including bilateral axillary, infraclavicular, internal mammary, and supraclavicular lymph nodes, were evaluated in 111 patients (mean age, 56 years). Of the 888 nodal basins, 625 (70%) were negative and 263 (30%) were positive for metastasis. Malignant lymph nodes had significantly higher SUVmax than benign lymph nodes (P .0001). An SUVmax of 2.0 showed the highest overall sensitivity (89%) and specificity (99%) for the diagnosis of malignant disease. Conclusions: SUVmax of regional lymph nodes on 18F-FDG PET/CT imaging may help differentiate benign and malignant lymph nodes in patients with inflammatory breast cancer. An SUV cutoff of 2 provided the best accuracy in identifying regional nodal metastasis in this patient population.
机译：理由和目标：本研究的目的是确定最佳的标准化摄取值（SUV）阈值，用于鉴定炎症患者的18F-氟脱氧葡萄糖（FDG）正电子发射断层（PET）/计算机断层摄影（CT）研究的区域节节转移阈值乳腺癌。材料和方法：对新诊断的患者进行数据库搜索，患有在2001年1月1日至2009年1月1日至2009年9月30日期间的单一机构诊断时接受了18F-FDG宠物/ CT成像的患者。三个放射科医生通过测量视觉异常节点中的最大SUV（SUVMAX）来回顾区域淋巴结的组织病理学回顾性地分析了所有18F-FDG PET / CT图像。 18F-FDG PET / CT图像解释的准确性与可用时的组织病理学相关。进行接收器操作特征曲线分析以评估PET / CT成像的诊断性能。使用三种不同的SUV截止值（2.0,2.5和3.0）计算敏感性，特异性，阳性预测值和否定预测值。结果：111名患者（平均年龄为56岁），评估了共有888个区域节点盆地，包括双侧腋窝，腋窝，内部乳腺和癌症淋巴结，并进行了两年龄次患者。在888个节点盆地中，625（70％）为阴性，263（30％）为转移阳性。恶性淋巴结显着高于良性淋巴结（P <.0001）。 2.0的Suvmax显示出最高敏感性（89％）和特异性（99％），用于诊断恶性疾病。结论：18F-FDG宠物/ CT成像的区域淋巴结的SUVMAX可能有助于炎症乳腺癌患者的患者良性和恶性淋巴结。 SUV截止2提供了在鉴定该患者人群中鉴定区域节点转移的最佳准确性。

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  • 来源
    《Academic radiology》 |2012年第5期|共7页
  • 作者

    CarkaciS.; AdradaB.E.; RohrenE.; WeiW.; QuraishiM.A.; MawlawiO.; BuchholzT.A.; YangW.;

  • 作者单位

    Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Unit 1350;

    Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Unit 1350;

    Department of Nuclear Medicine The University of Texas MD Anderson Cancer Center 1515 Holcombe;

    Department of Biostatistics The University of Texas MD Anderson Cancer Center 1515 Holcombe Blvd;

    Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Unit 1350;

    Department of Imaging Physics The University of Texas MD Anderson Cancer Center 1515 Holcombe;

    Department of Radiation Oncology Treatment The University of Texas MD Anderson Cancer Center 1515;

    Department of Diagnostic Radiology The University of Texas MD Anderson Cancer Center Unit 1350;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Inflammatory breast cancer; Lymph node metastasis; PET CT; SUV; Threshold;

    机译：炎症乳腺癌;淋巴结转移;宠物CT;SUV;阈值;

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