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首页> 外文期刊>Academic radiology >Liver Perfusion Imaging in Patients with Primary and Metastatic Liver Malignancy. Prospective Comparison between 99mTc-MAA SPECT and Dynamic CT Perfusion
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Liver Perfusion Imaging in Patients with Primary and Metastatic Liver Malignancy. Prospective Comparison between 99mTc-MAA SPECT and Dynamic CT Perfusion

机译：肝脏灌注成像在患有原发性和转移性肝脏恶性肿瘤的患者中。 99MTC-MAA SPECT和动态CT灌注的前瞻性比较

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摘要

Rationale and Objectives: To prospectively analyze the correlation between parameters of liver perfusion from technetium 99m-macroaggregates of albumin ( 99mTc-MAA) single photon emission computed tomography (SPECT) with those obtained from dynamic CT perfusion in patients with primary or metastatic liver malignancy. Materials and Methods: Twenty-five consecutive patients (11 women, 14 men; mean age 60.9 ± 10.8; range: 32-78 years) with primary (n = 5) or metastatic (n = 20) liver malignancy planned to undergo selective internal radiotherapy underwent dynamic contrast-enhanced CT liver perfusion imaging (four-dimensional spiral mode, scan range 14.8 cm, 15 scans, cycle time 3 seconds) and 99mTc-MAA SPECT after intraarterial injection of 180 MBq 99mTc-MAA on the same day. Data were evaluated by two blinded and independent readers for the parameters arterial liver perfusion (ALP), portal venous perfusion (PVP), and total liver perfusion (TLP) from CT, and the 99mTc-MAA uptake-ratio of tumors in relation to normal liver parenchyma from SPECT. Results: Interreader agreements for quantitative perfusion parameters were high for dynamic CT (r = 0.90-0.98, each P .01) and 99mTc -MAA SPECT (r = 0.91, P .01). Significant correlation was found between 99mTc-MAA uptake ratio and ALP (r = 0.7, P .01) in liver tumors. No significant correlation was found between 99mTc-MAA uptake ratio, PVP (r = -0.381, P = .081), and TLP (r = 0.039, P = .862). Conclusion: This study indicates that in patients with primary and metastatic liver malignancy, ALP obtained by dynamic CT liver perfusion significantly correlates with the 99mTc-MAA uptake ratio obtained by SPECT.
机译：理由和目的：前瞻性分析来自白蛋白的99m锝 - 大团聚肝灌注的参数之间的相关性（99mTc-MAA）单光子发射计算机断层摄影（SPECT），在患者的原发性或转移性肝癌恶性肿瘤从动态CT灌注获得的那些。材料和方法：二十五个连续病人（11名妇女，14名男性;平均年龄60.9±10.8;范围：32-78岁），初级（N = 5）或转移性（N = 20）肝恶性肿瘤计划经历选择性内部放疗进行动态对比增强CT肝灌注成像（四维螺旋模式，扫描范围14.8厘米，15次扫描，循环时间3秒）与99mTc-MAA SPECT在同一天180活度99mTc-MAA的动脉内注射后。数据由两个盲和独立读者参数动脉肝灌注（ALP），门静脉灌注（PVP），和总的肝灌注（TLP）从CT，和99mTc-MAA摄取比肿瘤相对于正常评价肝实质从SPECT。结果：定量灌注参数Interreader协议是高动态CT（R = 0.90-0.98，每个P＆LT; 0.01）与99mTc -MAA SPECT（R = 0.91，P＆LT; 0.01）。显著相关性99mTc-MAA之间发现摄取率和ALP相关（r = 0.7，P＆LT; 0.01）在肝肿瘤。无显著相关性99mTc-MAA之间发现摄取率，PVP（R = -0.381，p = 0.081），和TLP相关（r = 0.039，P = 0.862）。结论：本研究表明，在患者的原发性和转移性肝脏恶性肿瘤，通过动态CT肝脏灌注获得ALP显著与99mTc-MAA相关摄取SPECT获得的比值。

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  • 来源
    《Academic radiology》 |2012年第5期|共9页
  • 作者

    ReinerC.S.; GoettiR.; BurgerI.A.; FischerM.A.; FrauenfelderT.; KnuthA.; PfammatterT.; SchaeferN.; AlkadhiH.;

  • 作者单位

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

    Department of Nuclear Medicine University Hospital Zurich Raemistr. 100 CH-8091 Zurich;

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

    Clinic for Oncology University Hospital Zurich Raemistr. 100 CH-8091 Zurich Switzerland;

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

    Department of Nuclear Medicine University Hospital Zurich Raemistr. 100 CH-8091 Zurich;

    Institute of Diagnostic and Interventional Radiology University Hospital Zurich Raemistr. 100 CH;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    99mTc -MAA SPECT; Computed tomography; Liver; Malignant liver tumor; Perfusion;

    机译：99mtc-maa spect;计算断层扫描;肝脏;恶性肝肿瘤;灌注;

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