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Altered Excitation-inhibition Balance in the Brain of Patients with Diabetic Neuropathy

机译：糖尿病神经病变患者脑中改变了激发抑制平衡

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摘要

Rationale and Objectives: To assess differences in excitatory (glutamate/glutamine or Glx) and inhibitory (γ-Aminobutyric acid or GABA) neurotransmitter levels using MR spectroscopy in pain processing regions of the brain in patients diabetic neuropathy (DN) and positive sensory symptoms and age-matched healthy control (HC) subjects. Materials and Methods: Seven diabetic patients (5 males, 2 females, mean age = 57.0 ± 8.5 years) with confirmed DN and positive sensory symptoms and 7 age and sex matched HC subjects (mean age = 57.7 ± 3.2 years) underwent 3 Tesla MR spectroscopy. Glx and GABA levels were quantified in the right anterior and posterior insula, anterior cingulate cortex and right thalamus. Results: Mean Glx levels were significantly higher and mean GABA levels were significantly lower within the posterior insula in the DN patients compared to HC (P = 0.005 and 0.012 respectively). Conclusions: This pilot data demonstrates an excitatory/inhibitory neurotransmitter imbalance in the brain of in patients with DN and positive sensory symptoms compared to pain free HC subjects.
机译：理由和目标：评估兴奋性（谷氨酸/谷氨酰胺或GLX）和抑制（γ-氨基丁酸或GABA）神经递质水平的差异使用MR光谱在患者糖尿病神经病变（DN）和阳性感觉症状和阳性感觉症状中年龄匹配的健康控制（HC）受试者。材料和方法：七名糖尿病患者（5名男性，2名女性，平均年龄= 57.0±8.5岁），具有确认的DN和阳性感官症状和7岁和性别匹配的HC受试者（平均年龄= 57.7±3.2岁）接受了3个Tesla Mr光谱学。 GLX和GABA水平在右侧和后肠道中定量，前刺刺伤皮层和右丘脑。结果：平均GLX水平显着提高，与HC（P = 0.005和0.012）相比，DN患者的后肠内的平均GABA水平显着降低。结论：该导频数据在与无疼痛HC受试者相比，DN和阳性感官症状的脑内脑内兴奋/抑制性神经递质不平衡。

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  • 来源
    《Academic radiology》 |2012年第5期|共6页
  • 作者

    PetrouM.; Pop-BusuiR.; FoersterB.R.; EddenR.A.; CallaghanB.C.; HarteS.E.; HarrisR.E.; ClauwD.J.; FeldmanE.L.;

  • 作者单位

    Department of Radiology Division of Neuroradiology University of Michigan 1500 E. Medical Center;

    Department of Internal Medicine Division of Metabolism Endocrinology and Diabetes University of;

    Department of Radiology Division of Neuroradiology University of Michigan 1500 E. Medical Center;

    Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School;

    Department of Neurology University of Michigan 1500 E. Medical Center Drive SPC 5030 UH B2 A209;

    Department of Anesthesiology University of Michigan 1500 E. Medical Center Drive SPC 5030 UH B2;

    Department of Anesthesiology University of Michigan 1500 E. Medical Center Drive SPC 5030 UH B2;

    Department of Anesthesiology University of Michigan 1500 E. Medical Center Drive SPC 5030 UH B2;

    Department of Neurology University of Michigan 1500 E. Medical Center Drive SPC 5030 UH B2 A209;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Diabetes; MR spectroscopy; Neuropathy; Pain;

    机译：糖尿病;MR光谱学;神经病变;疼痛;

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