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Scatter correction associated with dedicated dual-source ct hardware improves accuracy of lung air measures

机译：与专用双源CT硬件相关的分散校正提高了肺气措施的准确性

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摘要

Rationale and Objectives: Accurate assessment of air density used to quantitatively characterize amount and distribution of emphysema in chronic obstructive pulmonary disease (COPD) subjects has remained challenging. Hounsfield units (HU) within tracheal air can be considerably less negative than -1000 HU. This study has sought to characterize the effects of improved scatter correction used in dual-source pulmonary computed tomography (CT). Materials and Methods: Dual-source dual-energy (DSDE) and single-source (SS) scans taken at multiple energy levels and scan settings were acquired for quantitative comparison using anesthetized ovine ( n=6), swine ( n=13), and a lung phantom. Data were evaluated for thelung, inferior vena cava, and tracheal segments. To minimize the effect of cross-scatter, the phantom scans in the DSDE mode were obtained by reducing the current of one of the tubes to near zero. Results: A significant shift in mean HU values in the tracheal regions of animals and the phantom is observed, with values consistently closer to -1000 HU in DSDE mode. HU values associated with SS mode demonstrated a positive shift of up to 32 HU. Invivo tracheal air measurements demonstrated considerable variability with SS scanning, whereas these values were more consistent with DSDE imaging. Scatter effects in the lung parenchyma differed from adjacent tracheal measures. Conclusion: Data suggest that the scatter correction introduced into the dual-energy mode of imaging has served to provide more accurate CT lung density measures sought to quantitatively assess the presence and distribution of emphysema in COPD subjects. Data further suggest that CT images, acquired without adequate scatter correction, cannot be corrected by linear algorithms given the variability in tracheal air HU values and the independent scatter effects on lung parenchyma.
机译：理由和目标：准确评估用于定量表征慢性阻塞性肺病（COPD）受试者的肺气肿的量和分布的量化和分布仍然具有挑战性。气管空气中的Hounsfield单位（Hu）可以比-1000胡少得多。本研究已经寻求表征改进的散射校正在双源肺计算断层扫描（CT）中的影响。材料和方法：采用多源双能（DSDE）和单源（DSDE）和单源（SS）扫描，用于使用麻醉绵羊（n = 6），猪（n = 13）进行定量比较，以进行定量比较。和一个肺幻影。评估了Thelung，verior Vena Cava和气管段的数据。为了使横向散射的效果最小化，通过将管道的电流降低到零附近，获得DSDE模式中的幻像扫描。结果：观察到动物气管区域的平均HU值的显着变化，在DSDE模式下，值始终更接近-1000UU。与SS模式相关的HU值展示了高达32胡锦涛的正档。 Invivo气管空气测量表现出与SS扫描相当可变性，而这些值与DSDE成像更加一致。肺实质中的散点效应与相邻的气管措施不同。结论：数据表明，引入到双能成像模式中的分散校正已经提供了更准确的CT肺密度措施，寻求定量评估肺气肿在COPD受试者中的存在和分布。数据进一步表明，在没有足够的散射校正的情况下获得的CT图像不能通过线性算法校正天气气相HU值的可变性和对肺实质的独立散射效应。

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  • 来源
    《Academic radiology》 |2013年第11期|共10页
  • 作者

    MobberleyS.D.; FuldM.K.; SierenJ.P.; PrimakA.N.; HoffmanE.A.;

  • 作者单位

    Department of Radiology Division of Physiological Imaging University of Iowa Hospitals and Clinics;

    Department of Radiology Division of Physiological Imaging University of Iowa Hospitals and Clinics;

    Department of Radiology Division of Physiological Imaging University of Iowa Hospitals and Clinics;

    Siemens Medical Solutions USA Malvern PA United States;

    Department of Radiology Division of Physiological Imaging University of Iowa Hospitals and Clinics;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    COPD; Dual energy; Emphysema; Lung density; Quantitative CT;

    机译：COPD;双能量;肺部;肺密度;定量CT;

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