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首页> 外文期刊>Acta biomaterialia >Density-property relationships in collagen-glycosaminoglycan scaffolds.
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Density-property relationships in collagen-glycosaminoglycan scaffolds.

机译：胶原甘油糖蛋白酶蛋白基骨架的密度 - 性质关系。

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Collagen-glycosaminoglycan scaffolds for the regeneration of skin have previously been fabricated by freeze-drying a slurry containing a co-precipitate of collagen and glycosaminoglycan. The mechanical properties of the scaffold are low (e.g. the dry compressive Young's modulus is roughly 30kPa and the dry compressive strength is roughly 5kPa). There is interest in using these scaffolds for tendon and ligament regeneration where there is a need for improved mechanical properties. Previous attempts to increase the mechanical properties of the scaffold by increasing the solid volume fraction of the scaffolds were limited by the increasing viscosity of the slurry, making it more difficult to mix and giving inhomogeneous scaffolds. Our recent work on mineralized collagen-glycosaminoglycan scaffolds used a vacuum filtration technique to increase the volume fraction of solids in the slurry, thereby increasing the density and mechanical properties of the scaffolds. In this work, we used this technique to fabricate collagen-glycosaminoglycan scaffolds with dry densities between 0.0076 and 0.0311gcm(-3) and pore sizes between 250 and 350microm, values appropriate for soft tissue growth. The compressive Young's modulus and strength in the dry state increased from 32 to 127kPa and from 5 to 19kPa, respectively, with increasing density. The tensile Young's modulus in the dry state increased from 295 to 3.1MPa with increasing density. Finally, we showed that the attachment of cells onto the scaffold was directly proportional to the specific surface area of the scaffold, which defines the total internal surface area per volume of scaffold.
机译：以先前通过冷冻干燥含有胶原蛋白和糖胺聚糖的共沉淀物的浆料来制造皮肤再生的胶原蛋白 - 糖酰胺基糖蛋白。支架的机械性能低（例如，干压缩杨氏模量大约是30kPa，干抗压强度大致为5kPa）。有兴趣使用这些支架用于肌腱和韧带再生，其中需要改进的机械性能。以前通过增加支架的固体体积分数来增加支架的机械性能的试图受到浆料的粘度的增加的限制，使得混合和赋予不均匀支架更难以。我们最近的矿化胶原蛋白 - 糖胺聚糖支架使用真空过滤技术，以增加浆料中固体的体积分数，从而增加支架的密度和机械性能。在这项工作中，我们使用该技术制造胶原糖氨基氨基蛋白酶高支架，其干燥密度在0.0076和0.0311gcm（-3）和250至350microm之间的孔径，适合于软组织生长的值。干燥状态的压缩杨氏模量和强度分别从32至127kPa增加到127kpa，并且分别从5到19kpa增加，密度增加。干燥状态下的拉伸杨氏模量从295增加到3.1MPa，密度增加。最后，我们表明，细胞附着到支架上与支架的比表面积成比例，其限定了每体积支架的总内表面积。

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