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首页> 外文期刊>Acta biomaterialia >A comparison of the effects of prosthetic and commercially pure metals on retrieved human fibroblasts: the role of surface elemental composition.
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A comparison of the effects of prosthetic and commercially pure metals on retrieved human fibroblasts: the role of surface elemental composition.

机译：假体和商业纯金属对检索人成纤维细胞的影响的比较：表面元素组成的作用。

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摘要

The most common clinical cause of long-term failure in total joint replacement surgery is inflammatory aseptic osteolysis; a condition in which bone surrounding the prosthetic implant, and to which the implant is attached, is resorbed, rendering the artificial device loose and painful. Historically, the severity of this bone resorptive process has been thought to be predominately attributed to the size and shape of wear-debris particles, particularly the metallic particulates that interact biologically/immunologically with cells in the joint. Because the cytotoxic reactions are the result of interactions between the cells and the surfaces of the particulates, it is not clear in the realm of orthopedics to what extent different surface stoichiometric ratios contribute to instigating bioreactive or cytotoxic cellular responses that can lead to aseptic osteolysis. Using energy dispersive X-ray spectroscopy (EDS) and X-ray photoelectron spectroscopy (XPS), this study presents data and analyses concerning the respective bulk and surface stoichiometric ratios of two commercially pure metal micro-particulates (tantalum and titanium), two prosthetic F75 cobalt-chromium-molybdenum alloy micro-particulates, and prosthetic F136 titanium-aluminum-vanadium alloy micro-particulates, each containing elements common to total joint replacement surgery. Cell culture viability data from four volunteer donors are also presented, which suggest that micro-particulates containing large percentages of surface titanium and aluminum can cause moderate cellular toxicity, and micro-particulates containing large percentages of surface cobalt can result in extremely severe cellular toxicity. This work further suggests that surface analysis techniques, such as XPS, are essential to determine surface elemental characterization of metallic materials prior to interpreting cellular response results.
机译：总关节置换手术的长期失效最常见的临床原因是炎症无菌骨溶解;将围绕假体植入物的骨骼以及附着植入物的骨头的条件进行了吸收，使人造装置松动，疼痛。从历史上看，已经认为这种骨吸收解过程的严重程度主要归因于磨损碎片颗粒的尺寸和形状，特别是与关节中的细胞相互作用/免疫的金属颗粒。因为细胞毒性反应是细胞与颗粒的表面之间相互作用的结果，所以在整形外科的领域中尚不清楚不同的表面化学计量比率有助于煽动可以导致无菌osteolys的生物反应或细胞毒性细胞反应。使用能量分散X射线光谱（EDS）和X射线光电子能谱（XPS），本研究介绍了两种商业纯净金属微颗粒（钽和钛）的各自的体积和表面化学计量比的数据和分析。 F75钴 - 铬 - 钼合金微颗粒，以及假体F136钛 - 铝 - 钒合金微颗粒，每种含有总关节置换手术共同的元素。还提出了来自四种志愿者供体的细胞培养活力数据，这表明含有大百分比的表面钛和铝的微颗粒会引起中等细胞毒性，并且含有大百分比的表面钴的微颗粒可导致细胞毒性极其严重的细胞毒性。这项工作进一步表明，在解释细胞响应结果之前，表面分析技术（如XPS）是必不可少确定金属材料的表面元素表征。

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