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首页> 外文期刊>Acta biomaterialia >Versatile biomimetic cantharidin-tellurium nanoparticles enhance photothermal therapy by inhibiting the heat shock response for combined tumor therapy
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Versatile biomimetic cantharidin-tellurium nanoparticles enhance photothermal therapy by inhibiting the heat shock response for combined tumor therapy

机译：多功能杀生物纤维素碲素 - 碲纳米粒子通过抑制组合肿瘤治疗的热休克响应来增强光热疗法

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摘要

The heat shock response (HSR) induced by photothermal therapy (PTT), which can cause tumor cells to resist apoptosis, has increasingly attracted the attention of researchers. Synergistic treatment of tumors using multiple means to improve therapeutic efficiency would be a promising strategy for effective cancer treatment. In this study, a cancer cell membrane-camouflaged nanocarrier was developed and loaded with tellurium (Te) and cantharidin (CTD) for efficient combinatorial therapy. The designed nanoparticles (m-CTD@Te) used a 4T1 cell membrane coating as the shell with homologous targeting capability, CTD as an the HSR inhibitor and antitumor drug, and Te as a PIT and photodynamic therapy (PDT) photosensitizer. An in vivo study indicated that the tumor inhibition rate of this combinatorial therapy could reach approximately 82.3% in 4T1 mammary tumor models. This study suggested that m-CTD@Te, as a versatile biomimetic nanoplatform, provides a new alternative for more precise and effective tumor treatment.
机译：通过光热疗法（PTT）引起的热休克反应（HSR），可导致肿瘤细胞抵抗细胞凋亡，越来越多地引起了研究人员的注意。使用多种手段改善治疗效率的肿瘤的协同处理将是有效癌症治疗的有希望的策略。在该研究中，癌细胞膜 - 伪装的纳米载流纳米骨架被开发并加载碲（TE）和Cantharidin（CTD）以进行有效的组合治疗。设计的纳米颗粒（M-CTD @ TE）使用了4T1细胞膜涂层作为壳体，具有同源靶向能力，CTD作为HSR抑制剂和抗肿瘤药物，以及作为坑和光动力治疗（PDT）光敏剂的TE。体内研究表明，这种组合治疗的肿瘤抑制率可以在4T1乳腺肿瘤模型中达到约82.3％。该研究表明，M-CTD @ TE，作为通用的仿生纳米片，为更精确有效的肿瘤治疗提供了一种新的替代方案。

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