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首页> 外文期刊>Acta biomaterialia >Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications
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Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications

机译：生物医学应用中的3D印刷高强度和弹性水凝胶的最新进展

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摘要

Three-dimensional (3D) printing enables the production of personalized tissue-engineered products with high tunability and complexity. It is thus an attractive and promising technology in the pharmaceutical and medical fields. Printable and biocompatible hydrogels are attractive materials for 3D printing applications because they offer favorable biomimetic environments for live cells, such as high water content, porous structure, bioactive molecule incorporation, and tunable mechanical properties and degradation rates. However, most conventional hydrogel materials are brittle and mechanically weak and hence cannot meet the mechanical needs for handling and soft and elastic tissue use. Thus, the development of printable, high-strength, and elastic hydrogel materials for 3D printing in tissue repair and regeneration is critical and interesting. In this review, we summarized the recent reports on high-strength and elastic hydrogels for printing use and categorized them into three groups, namely double-network hydrogels, nanocomposite hydrogels, and single-network hydrogels. The reinforcing mechanisms of these high-strength hydrogels and the strategies to improve their printability and biocompatibility were further discussed. These high-strength and elastic hydrogels may offer opportunities to accelerate the development of 3D printing technology and provide new insights for 3D-printed product design in biomedicine.
机译：三维（3D）印刷能够生产具有高可调性和复杂性的个性化组织工程产品。因此，制药和医疗领域是一种有吸引力和有希望的技术。可印刷和生物相容性水凝胶是用于3D打印应用的吸引力，因为它们为活细胞提供了有利的生物摩米素环境，例如高水含量，多孔结构，生物活性分子掺入和可调谐机械性能和降解速率。然而，大多数常规的水凝胶材料是脆性的，机械弱，因此不能满足机械需求，用于处理和柔软和弹性组织使用。因此，在组织修复和再生中的3D印刷的可印刷，高强度和弹性水凝胶材料的发展是关键和有趣的。在本综述中，我们总结了最近关于高强度和弹性水凝胶的报道，用于印刷使用，并将它们分为三组，即双网络水凝胶，纳米复合水凝胶和单一网络水凝胶。进一步讨论了这些高强度水凝胶的增强机制和改善其可印刷性和生物相容性的策略。这些高强度和弹性水凝胶可以提供加速3D印刷技术的发展的机会，为生物医学的3D印刷产品设计提供新的见解。

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