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首页> 外文期刊>Acta biomaterialia >Antibacterial biohybrid nanofibers for wound dressings
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Antibacterial biohybrid nanofibers for wound dressings

机译：伤口敷料的抗菌生物喂养纳米纤维

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Globally, chronic wounds impose a notable burden to patients and healthcare systems. Such skin wounds are readily subjected to bacteria that provoke inflammation and hence challenge the healing process. Furthermore, bacteria induce infection impeding re-epithelialization and collagen synthesis. With an estimated global market of $20.4 billion by 2021, appropriate wound dressing materials e.g. those composed of biopolymers originating from nature, are capable of alleviating the infection incidence and of accelerating the healing process. Particularly, biopolymeric nanofibrous dressings are biocompatible and mostly biodegradable and biomimic the extracellular matrix structure. Such nanofibrous dressings provide a high surface area and the ability to deliver antibiotics and antibacterial agents locally into the wound milieu to control infection. In this regard, with the dangerous evolution of antibiotic resistant bacteria, antibiotic delivery systems are being gradually replaced with antibacterial biohybrid nanofibrous wound dressings. This emerging class of wound dressings comprises biopolymeric nanofibers containing antibacterial nanoparticles, nature-derived compounds and biofunctional agents. Here, the most recent (since 2015) developments of antibacterial biopolymeric nanofibrous wound dressings, particularly those made of biohybrids, are reviewed and their antibacterial efficiency is evaluated based on a comprehensive literature analysis. Lastly, the prospects and challenges are discussed to draw a roadmap for further progresses and to open up future research avenues in this area.
机译：在全球范围内，慢性伤口对患者和医疗保健系统施加了显着的负担。这种皮肤伤口容易受到挑起炎症的细菌，因此挑战愈合过程。此外，细菌诱导阻碍重新上皮和胶原合成的感染。估计到2021年的全球市场为204亿美元，适当的伤口敷料材料。由源自自然的生物聚合物组成的那些能够减轻感染发病率和加速愈合过程。特别是，生物聚合物纳米纤维敷料是生物相容性的，并且大多是可生物降解的和生物化的细胞外基质结构。这种纳米纤维敷料提供高表面积和局部递送抗生素和抗菌剂进入伤口环境中的能力以控制感染。在这方面，随着抗生素抗性细菌的危险演变，抗生素递送系统逐渐用抗菌生物喂养纳米纤维卷绕敷料替换。该新出现的伤口敷料包括含有抗菌纳米颗粒，自然衍生的化合物和生物偶突剂的生物聚合物纳米纤维。在这里，综合评估了抗菌生物聚合物纳米纤维纳米纤维卷绕敷料，特别是由生物冬胺制成的抗菌生物纳米纤维伤口敷料的开发，并根据综合文献分析评估其抗菌效率。最后，讨论了前景和挑战，以绘制一个路线图，以进一步进步，并在该地区开辟未来的研究途径。

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