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首页> 外文期刊>Acta biomaterialia >Controllable biodegradation and enhanced osseointegration of ZrO2-nanofilm coated Zn-Li alloy: In vitro and in vivo studies
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Controllable biodegradation and enhanced osseointegration of ZrO2-nanofilm coated Zn-Li alloy: In vitro and in vivo studies

机译：ZrO2纳米丝涂层Zn-Li合金的可控生物降解和增强骨整合：体外和体内研究

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摘要

Zinc and its alloys have emerged as a new research direction of biodegradable metals (BMs) due to the significant physiological functions of Zn2+ ions in human body. However, low inhibitory concentration threshold value to cause cytotoxicity by Zn2+ ions during in vitro study and delayed osseointegration in vivo are two key flaws for the bulk Zn-based BMs. To combat these issues, we constructed a barrier layer of ZrO2 nanofilm on the surface of Zn-0.1(wt.%) Li alloy via atomic layer deposition (ALD). A decreased release of Zn2+ ions accompanied with accelerated release of Li+ ions was observed on account of galvanic coupling between the coating compositions and Zn-0.1Li alloy substrate. Cytocompatibility assay reflected that ZrO2 nanofilm coated Zn-0.1Li alloy exhibited improved cell adhesion and viability. Histological analysis also demonstrated better in vivo osseointegration for the ZrO2 nanofilm coated Zn-0.1Li alloy. Hence, the present study elucidated that the ALD of ZrO2 nanofilm on Zn-based BMs can effectively promote osseointegration and control their biodegradation behavior.
机译：由于Zn2 +离子在人体中的显着生理功能，锌及其合金已经成为可生物降解金属（BMS）的新研究方向。然而，在体外研究期间通过Zn2 +离子引起细胞毒性的低抑制浓度阈值，并且体内延迟骨整合是基于体Zn的BMS的两个关键缺陷。为了解决这些问题，我们通过原子层沉积（ALD）在Zn-0.1（重量％）Li合金表面上构建了ZrO2纳米丝的阻挡层。由于涂料组合物和Zn-0.1LI合金基材之间的电偶联，观察到伴随加速释放Li +离子的Zn2 +离子的释放。细胞锁定测定反映了ZrO2纳米丝涂覆的Zn-0.1LI合金，其表现出改善的细胞粘附和活力。组织学分析还更好地在ZrO2纳米丝涂覆的Zn-0.1Li合金中进行了更好的体内骨整合。因此，本研究阐明了ZrO2纳米丝对基于Zn的BMS的ALD可以有效地促进骨整合并控制其生物降解行为。

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  • 来源
    《Acta biomaterialia》 |2020年第2020期|共14页
  • 作者

    Yuan Wei; Xia Dandan; Zheng Yufeng; Liu Xiangmei; Wu Shuilin; Li Bo; Han Yong; Jia Zhaojun; Zhu Donghui; Ruan Liqun; Takashima Kazuki; Liu Yunsong; Zhou Yongsheng;

  • 作者单位

    Peking Univ Coll Engn Dept Mat Sci &

    Engn Beijing 100871 Peoples R China;

    Peking Univ Coll Engn Dept Mat Sci &

    Engn Beijing 100871 Peoples R China;

    Peking Univ Coll Engn Dept Mat Sci &

    Engn Beijing 100871 Peoples R China;

    Hubei Univ Minist Educ Key Lab Green Preparat &

    Applicat Funct Mat Hubei Key Lab Polymer Mat Sch;

    Tianjin Univ Minist Educ China Key Lab Adv Ceram &

    Machining Technol Sch Mat Sci &

    Engn Tianjin;

    Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China;

    Xi An Jiao Tong Univ State Key Lab Mech Behav Mat Xian 710049 Peoples R China;

    Rutgers State Univ Dept Chem &

    Chem Biol Piscataway NJ 08854 USA;

    SUNY Stony Brook Dept Biomed Engn Inst Engn Driven Med Coll Engn &

    Appl Sci Renaissance Sch Med;

    Kumamoto Univ Grad Sch Sci &

    Technol Dept Mech Syst Engn Kurokami 2-39-1 Kumamoto 8608555 Japan;

    Kumamoto Univ Fac Engn Dept Mat Sci &

    Engn 2-39-1 Kurokami Kumamoto 8608555 Japan;

    Peking Univ Sch &

    Hosp Stomatol Dept Prosthodont Beijing 100081 Peoples R China;

    Natl Clin Res Ctr Oral Dis Beijing Key Lab Digital Stomatol Natl Engn Lab Digital &

    Mat Technol;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Zn-Li alloy; Zirconia nanofilm; Atomic layer deposition; Biodegradation; Biocompatibility; Orthopedic implants;

    机译：Zn-Li合金;氧化锆纳米丝;原子层沉积;生物降解;生物相容性;骨科植入物;

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