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首页> 外文期刊>Acta biomaterialia >Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy
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Co-delivery of doxorubicin and DNAzyme using ZnO@polydopamine core-shell nanocomposites for chemo/gene/photothermal therapy

机译：使用ZnO @聚二胺核心 - 壳纳米复合材料进行多柔比蛋白和DNazyme的共同递送，用于化学/基因/光热疗法

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摘要

Multi-modal nanomedicines that synergistically combine chemo-, gene-, and photothermal therapy have shown great potential for cancer treatment. In this study, a core-shell nanosystem-based on a zinc oxide (ZnO) nanocore and a polydopamine (PDA) shell was constructed to integrate chemo- (doxorubicin, DOX), gene- (DNAzyme, DZ), and photothermal (PDA layer) therapy in one system. Instead of small interfering RNAs, we employed DZ for tumor-related gene (survivin) regulation owing to its higher stability, biocompatibility, and predictable activity. DOX and amino-modified DZ were loaded onto the PDA shell via physisorption and covalent conjugation, respectively. Specifically, the ZnO nanocore was designed as a metal cofactor reservoir to release Zn2+ in response to intracellular stimuli, which triggered the activation of DZ for gene silencing after endocytosis into cells. Both in vitro and in vivo experiments demonstrated the enhanced anti-tumor efficacy of these multifunctional nanocomposites and highlighted the advantages of these nano-drug delivery systems to alleviate the side effects of DOX. This study provides a strategy for synergistic cancer therapy via chemo/gene/photothermal combination and offers a strategy to harness DZ as a gene-silencing tool for disease treatment in combination with other therapeutic modalities.
机译：协同结合化疗，基因和光热疗的多模态纳米型肾上腺素显示出癌症治疗的巨大潜力。在该研究中，构建基于氧化锌（ZnO）纳米核和多氨基胺（PDA）壳的核 - 壳纳米系统，以整合化学 - （多柔比星，DOX），基因 - （DNAzyme，DZ）和光热（PDA层次）在一个系统中进行治疗。由于其较高的稳定性，生物相容性和可预测的活性，我们使用DZ而不是小干扰RNA，而不是小干扰RNA。 DOX和氨基修饰的DZ分别通过理物理和共价缀合在PDA壳上。具体地，ZnO Nanocore被设计为金属辅因子储存器，以响应细胞内刺激而释放Zn2 +，这引发了在内吞作用后的基因沉默中的DZ激活。体外和体内实验中的两种情况都证明了这些多功能纳米复合材料的增强抗肿瘤效果，并突出了这些纳米药物递送系统的优点，以缓解DOX的副作用。本研究提供了通过化学/基因/光热组合提供协同癌症治疗的策略，并为疾病治疗的基因沉默工具提供了一种策略，用于与其他治疗方式组合的疾病治疗。

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