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首页> 外文期刊>Acta biomaterialia >In vivo degradation performance of micro-Arc-oxidized magnesium implants: A micro-CT study in rats
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In vivo degradation performance of micro-Arc-oxidized magnesium implants: A micro-CT study in rats

机译：微电弧氧化镁植入物的体内降解性能：大鼠的微型CT研究

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摘要

Biodegradable Mg alloys are of great interest for osteosynthetic applications because they do not require surgical removal after they have served their purpose. In this study, fast-degrading ZX50 Mg-based implants were surface-treated by micro-Arc oxidation (MAO), to alter the initial degradation, and implanted along with untreated ZX50 controls in the femoral legs of 20 male Sprague-Dawley rats. Their degradation was monitored by microfocus computed tomography (??CT) over a total observation period of 24 weeks, and histological analysis was performed after 4, 12 and 24 weeks. While the MAO-treated samples showed almost no corrosion in the first week, they revealed an accelerated degradation rate after the third week, even faster than that of the untreated ZX50 implants. This increase in degradation rate can be explained by an increase in the surface-Area-to-volume ratio of MAO-treated implants, which degrade inhomogeneously via localized corrosion attacks. The histological analyses show that the initially improved corrosion resistance of the MAO implants has a positive effect on bone and tissue response: The reduced hydrogen evolution (due to reduced corrosion) makes possible increased osteoblast apposition from the very beginning, thus generating a stable bone-implant interface. As such, MAO treatment appears to be very interesting for osteosynthetic implant applications, as it delays implant degradation immediately after implantation, enhances fracture stabilization, minimizes the burden on the postoperatively irritated surrounding tissue and generates good bone-implant connections, followed by accelerated degradation in the later stage of bone healing. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：可生物降解的Mg合金对骨质合成应用具有很大的兴趣，因为它们在担任其目的之后不需要手术删除。在该研究中，通过微弧氧化（MAO）表面处理快速降解的ZX50mg植入物，以改变初始降解，并植入在20只雄性Sprague-Dawley大鼠的股骨腿中的未处理的ZX50对照。通过微焦度计算断层扫描（CT）监测其降解在24周的总观察期，组织学分析在4,12和24周后进行。虽然毛泽地治疗的样品在第一周出现几乎没有腐蚀，但它们在第三周后揭示了加速的降解速率，甚至比未经治疗的ZX50植入物更快。降解率的这种增加可以通过茂地处理植入物的表面积到体积比的增加来解释，其通过局部化腐蚀攻击均可均可渗透地降低。组织学分析表明，MAO植入物的初始改善对骨和组织反应的阳性作用：降低的氢进化（由于腐蚀的降低），从一开始就可能增加了成骨细胞置波，从而产生稳定的骨 - 植入界面。因此，对于骨酸合成植入物应用似乎非常有趣，因为它延迟植入后立即植入降解，提高骨折稳定，最大限度地减少垂直周围组织的负担，并产生良好的骨植入连接，然后加速降解骨愈合的后期阶段。还2012年Acta Materialia Inc.出版的Altevier Ltd.保留所有权利。

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  • 来源
    《Acta biomaterialia》 |2013年第2期|共10页
  • 作者

    FischerauerS.F.; KrausT.; WuX.; TanglS.; SorantinE.; H?nziA.C.; L?fflerJ.F.; UggowitzerP.J.; WeinbergA.M.;

  • 作者单位

    Department of Pediatric and Adolescent Surgery Medical University Graz Auenbruggerplatz 5/6 A;

    Department of Pediatric Orthopedics Medical University Graz Auenbruggerplatz 34 A-8036 Graz;

    Department of Oral and Maxillofacial Surgery Medical University of Innsbruck Anichstra?e 35 A;

    Institute of Cell Biology Histology and Embryology Medical University of Graz Harrachgasse 21 A;

    Department of Pediatric Radiology Medical University of Graz Auenbruggerplatz 34 A-8036 Graz;

    Laboratory of Metal Physics and Technology Department of Materials ETH Zurich Wolfgang-Pauli-Str;

    Laboratory of Metal Physics and Technology Department of Materials ETH Zurich Wolfgang-Pauli-Str;

    Laboratory of Metal Physics and Technology Department of Materials ETH Zurich Wolfgang-Pauli-Str;

    Department of Orthopedics Medical University Graz Auenbruggerplatz 5/6 A-8036 Graz Austria;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Biodegradation; In vivo animal imaging; Magnesium; Micro-Arc oxidation; Micro-computed tomography;

    机译：生物降解;体内动物成像;镁;微电弧氧化;微观计算断层扫描;

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